β-secretase相关论文
Background: Berberine(BBR)has neuroprotective effects on a variety of brain diseases,including Alzheimers disease(AD).Th......
Effects of mild induced hypothermia treatment on rat hippocampal β-amyloid expression following trau
Background: Mild induced hypothermia (MIH) treatment has positive effects on traumatic brain injury (TBI) outcomes, whic......
Amyloid-beta (Aβ) plays a pivotal role in the pathogenesis of Alzheimer\'s disease (AD) and has been regarded as the ......
The β‐secretase,β‐site amyloid precursor protein(APP)cleaving enzyme 1(BACE1),is the first of two proteases(the ......
Effects of chronic cerebral hypoperfusion of beta- and gamma-secretase on learning and memory in rat
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目的 探讨巨细胞病毒诱导的β-分泌酶在小鼠体内的变化及在藻酸双酯钠(PSS)治疗后淀粉样蛋白前体(APP)和β-分泌酶(BACE-1)的表达.......
Construction of a small peptide library related to inhibitor OM99-2 and its structure-activity relat
Aim: To develop probes for detecting the binding specificity between β-secretase and substrate, and provide reliable bi......
Microsecond molecular dynamics simulation of Aβ42 and identification of a novel dual inhibitor of ag
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Iron dysregulates APP processing accompanying with sAPPα cellular retention and β-secretase inhibiti
Amyloid precursor protein (APP) and iron both play pivotal roles in the central nervous system,but whether and how iron ......
Structural Features of Human Memapsin 2 (β-Secretase) and Their Biological and Pathological Implicat
Memapsin 2 (β-secretase) is the membrane-anchored aspartic protease that initiates the cleavage of β-amyloid precursor......
Effects of chronic cerebral hypoperfusion of beta- and gamma-secretase on learning and memory in rat
BACKGROUND: Chronic cerebral hypoxia and ischemia have been shown to be related to occurrence of sporadic Alzheimer's di......
目的 探讨β淀粉样前体蛋白裂解酶(β-site APP cleaving enzyme,BACE)的短干扰RNA(short interfering RNAs,siRNA)对BACE在神经母......
There are several major pathological changes in Alzheimer’s disease, including apoptosis of cho-linergic neurons, overa......
Precise location of proton of beta-secretase for catalytic aspartates (Asp 32 and Asp 228) in Alzhei
BACKGROUND:β-secretase (β-site APP cleavage rate-limiting enzyme, BACE) has been proposed as a promising therapeutic t......
选择活性跨越0．002至25μmol·L^-1的4类共25个口分泌酶抑制剂作为训练集，使用Catalyst软件包构建出药效团模型，并通过对药效团的......
目的探讨人参皂甙Rb1对AD大鼠顶叶皮质β-分泌酶及PS-1表达的影响。方法30只健康雄性SD大鼠，随机分为对照组、模型组和治疗组。模型......
目的 深入探讨基于羟基亚乙基二肽的β-分泌酶抑制剂的合成方法。方法综合使用多种有机合成反应来合成拟肽类β-分泌酶抑制剂，包括......
阿尔茨海默病(AD)是以认知功能障碍和记忆损害为特征的神经退行性疾病,是老年人中常见的一种痴呆症.β-淀粉样蛋白(Aβ)的沉积被认......
目的：研究α3神经型尼古丁受体（nAChR）基因沉默对β分泌酶（BACE）蛋白表达的影响。方法：稳定转染α3 nAChR siRNA表达质粒及空质粒的SH-SY......
目的：探讨人参皂甙Rb1对老年性痴呆模型大鼠顶叶皮质p分泌酶及早老蛋白-1（PS-1）表达水平的影响。方法：30只SD大鼠随机分为对照组、模型......
目的研究大鼠缺血损伤后脑内星形胶质细胞中β-淀粉样蛋白（Ala）的形成是否与β-分泌酶的增加相关。方法采用大脑中动脉栓塞30min制备......
β-Secretase (BACE1 or β-site APP cleaving enzyme) is an acid protease that releases the neurotoxic 40 - 42 residue pep......
Neurodegenerative diseases such as Alzheimer's,Huntington's and Parkinson's diseases have multifaceted natur......
为了获得有活性的重组β-secretase并研究其功能,寻找特异性抑制剂,应用RT-PCR技术,从人胚胎脑组织特异性扩增并克隆了人BACE1编码......
Computational Assessment and Pharmacological Property Breakdown of Eight Patented and Candidate Drug
Alzheimer’s Disease (AD) is the most prevalent age-related dementia. AD can be caused by abnormal processing of amyloid......
