transdifferentiation相关论文
Transforming growth factor beta 1 induced differentiation of Telomerase-Immortalized swine umbilical
Swine umbilicus veins were isolated in sterile, 0.1% collagenase I was poured into umbilicus vein to digest, primary swi......
Dose-dependent effect of estrogen suppresses the osteo-adipogenic transdifferentiation of BMMSCs fro
Aims: The plasticity observed between adipocytes and osteoblasts differentiation is the basis of transdifferentiation,ob......
Vasculogenic mimicry of tumor stem/progenitor cells contribute to angiogenesis of gliomas via transd
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Lysyl oxidase inhibition drives the transdifferentiation from lung adenocarcinoma to squamous cell c
Objective Lkb1 deficiency is the only well-established factor in driving lung adenocarcinoma(ADC)to squamous cell carcin......
Studies of induced pluripotent stem cells(iPSCs)and more recent findings that 356 defined transcription factors can dire......
Astrocytes are an important player in the reconstruction of neurovascular networks in adult rats aft
Neurovascular unit mainly includes neuron,astrocytes and vascular endothelial cells.Brain functional repair after injury......
P311 induces transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating
Myofibroblast function is closely related to wound healing and fibrosis.Emerging evidence indicates that epithelial-mese......
Transdifferentiation is the direct conversion from one somatic cell type into another desired somatic cell type.This rep......
The effects and mechanism of miR155 on thefibroblasts-to-myofibroblasts transition in dermal fibrobl
Hypertrophic scar, which is a troublesome problem in the field of tissue repairthat urgently need to be solved.Present s......
Background:Myogenic transdifferentiation can be accomplished through ectopic MYOD1 expression, which is facilitated by v......
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A novel, multifactorial approach for human iPS cell differentiation and reprogramming using an autom
In vitro studies using pluripotent stem cells provide an essential tool for understanding hard-tostudy in vivo devel......
Understanding the contribution of endothelial cells to the progenitor pools of adult tissues has the potential to inform......
Notch pathway inhibitor DAPT enhances Atoh1 activity to generate new hair cells in situ in rat cochl
Atoh1 overexpression in cochlear epithelium induces new hair cell formation. Use of adenovirus-mediated Atoh1 overexpres......
Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into m
Background:Motor neuron degeneration or loss in the spinal cord is the characteristic phenotype of motor neuron diseases......
目的:观察高磷刺激大鼠血管平滑肌细胞(VSMCs)后表型转化相关基因的动态变化,探讨VSMCs的表型转化方向.方法:组织块贴壁法原代培养......
目的观察不同浓度缬沙坦体外干预高糖环境下小鼠足细胞间充质细胞转分化及转化生长因子-β1(TGF-β)/Smad信号通路的调节作用。方......
Many neurodegenerative disorders such as Parkinson’s disease (PD),amyotrophic lateral sclerosis (ALS) and others often ......
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
Background Studies on human, rat and chicken embryos have demonstrated that during the period of outflow tract septatio......
Differentiation of bone marrow-derived mesenchymal stem cells from diabetic patients into insulin-pr
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Objective To analyze the expression of different proteins in free silica-induced transdifferentiated rat lung fibroblast......
Pdx1是较早发现的决定胰腺分化发育的关键转录因子.近年的研究发现Pdx1不仅是促进胰腺β细胞的胰岛素、生长抑素、葡萄糖激酶等基......
目的探讨α-硫辛酸(ALA)对高糖诱导的肾小管上皮细胞转分化的影响。方法体外培养人肾小管上皮细胞株(HKC)分别予正常糖(NG组)、高......
Role of Insulin-like Growth Factor II Receptor in Transdifferentiation of Free Silica-induced Primar
Objective To study the role of insulin-like growth factor II receptor in free silica-induced transdifferentiation of pri......
目的：观察Smad7在TGF-β致近端小管上皮细胞转分化中的变化，泛素系统对该过程中Smad信号的调节及对TGF-β所致的小管上皮细胞转分化......
目的：探讨间歇性高糖诱导大鼠肾小管上皮细胞株NRK-52EA转分化干预作用。方法：NRK-52E细胞分为空白组、正常葡萄糖组、高糖组、间歇......
目的探讨血管紧张素Ⅱ（AngⅡ）对高糖诱导大鼠肾小管导管上皮细胞株NRK-52E转分化的干预作用。方法细胞培养72 h后,Western blot检测......
目的 探讨小鼠骨髓间充质干细胞（bone marrow mesenchymal stem cells，BMSCs）在肝内分化为肝细胞的可行性。方法腹腔注射丙烯醇致雌性......
目的：通过观察雷公藤多苷对UUO小鼠肾小管间质细胞表型转化的影响，探讨抗风湿中药在防治肾间质纤堆化中的作用。方法：采用小鼠单侧输......
对有关干细胞可塑性的不同观点进行了概述，并关注了干细胞潜能和细胞表型多样性传统观点上的争议.讨论了在当前公认动物模型上观察......
目的探讨体外培养的毛囊bulge细胞向角膜上皮细胞分化的可能性.方法体外分离培养毛囊bulge细胞,然后在transwell中与角膜缘基质细......
目的观察大鼠晶状体摘出术后晶状体上皮细胞（lens epithelial cells，LECs）的形态、分布改变及其转分化的动态过程。方法对50只SD大鼠......
随着干细胞生物学研究的不断深入，成体干细胞被发现可以分化戍组织来源与其无关的其他系统的细胞，即戍体干细胞的可塑性。但是最近不......
目的：研究人羊膜上皮细胞（hAECs）体外诱导分化为唾液腺腺泡细胞样细胞的可能性。方法：分离hAECs并体外培养、鉴定。与8 d龄SD大鼠下颌......
传统观点认为，成体组织中的干细胞具有有限分化潜能，只能分化产生其所在组织中的某个或某些特定的细胞。近年来随着研究的深入，人们发......
目的：观察肾疏宁防治肾小球硬化的作用机制.方法：采用单侧肾切除并阿霉素尾静脉注射建立大鼠肾小球硬化模型,观察肾疏宁给药8周后肾......
上皮细胞在特定生理和病理情况下向间充质细胞转分化的现象是肿瘤及慢性炎症性疾病中的重要细胞生物学现象.近年来研究发现,细胞内......
干细胞是一类具有自我复制和多分化潜能的细胞,根据其发育阶段不同,分为胚胎干细胞和成体干细胞.胚胎干细胞具有多分化潜能;而成体......
<正>肾小管上皮细胞作为肾脏固有成分之一,其形态和功能的正常对于维持肾脏正常的结构和功能起着十分重要的作用。肾小管上皮细胞......
目的探讨阿利吉仑对转化生长因子-β1TGF-β1诱导人近端肾小管上皮细胞（HKC）转分化的作用及其对血小板源性生长因子-BB（PDGF-BB）、血管......
目的研究丹参酮ⅡA（TanⅡA）对血管紧张素Ⅱ（AngⅡ）诱导的大鼠心肌间质成纤维细胞α-平滑肌动蛋白（SMA）表达的影响。方法体外培养大鼠心肌......
Role of Insulin-like Growth Factor II Receptor in Transdifferentiation of Free Silica-induced Primar
在主要老鼠肺成纤维细胞方法老鼠肺成纤维细胞和老鼠的免费导致硅石的 transdifferentiation 学习像胰岛素的生长因素 II 受体的角......
目的将在免费导致硅石的 transdifferentiated 老鼠肺成纤维细胞分析不同蛋白质的表示。方法老鼠肺成纤维细胞和牙槽的巨噬细胞是......
骨髓干细胞的可塑性是近年来干细胞研究领域的重要发现,为利用骨髓干细胞治疗严重危害人类健康的非造血系统的疾病提供了可能性;骨......
上皮细胞在特定生理和病理情况下向间充质细胞转分化的现象是肿瘤及慢性炎症性疾病中的重要细胞生物学现象。近年来研究发现，细胞内......
研究小鼠胚胎成纤维细胞与新生小鼠心肌细胞共培养、并过表达心肌特异性转录因子对小鼠胚胎成纤维细胞向心肌细胞转分化效率的影响......
目的研究成体骨骼肌肌源性干细胞（MDSCs）向神经细胞分化的潜能。方法从成年SD大鼠骨骼肌组织中培养出肌源性干细胞,采用bFGF、EGF诱......
目的：观察乙醛对大鼠肝星状细胞株（HSC-T6）激活、增殖并转分化为肌成纤维细胞的影响。方法：HSC—T6细胞常规培养及乙醛处理；VG染色法形......
