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Protective effects of a polysaccharide from Spirulina platensis on dopaminergic neurons in an MPT-Pi
The present study aimed to determine whether a polysaccharide obtained from Spirulina platensis shows protective effects......
惊厥是儿科常见的急重症,发生率高达4%,反复的惊厥性损伤不但影响患儿的智力发育,而且严重惊厥可引起永久性脑损伤,留有后遗症,给......
Iptakalim alleviates rotenone-induced degeneration of Dopaminergic neurons through inhibiting microg
Inhibition of microglia-mediated neuroinflammation has been regarded as a prospective strategy for treating neurodegener......
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Mechanisms of secondary damage to the thalamic nucleus and substantia nigra in an adult hypertensive
BACKGROUND: Following ischemia, apoptosis is observed at the ipsilateral ventroposterior thalamic nucleus and substantia......
【正】 On August 27th,Royal DSM N.V.,the global Life Sciences and Materi-als Sciences Company headquartered in the Nethe......
Differential protein expression in substantia nigra induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahyd
...
反实体、反本质主义是现当代西方哲学反对传统哲学的重要标志。反实体几乎也已成了我国学术界的共识。反本质主义在我国学术界则尚......
OBJECTIVE: The motor symptoms of Parkinson’s disease (PD) can be improved by cell transplantation, which has caught gen......
Parkinson’s disease (PD) is a slowly progressive neurodegenerative disorder characterized clinically by bradykinesia, r......
Divalent metal transporter 1 expression and iron deposition in the substantia nigra of a rat model o
Extensive iron deposition has been observed in the midbrain substantia nigra(SN) of Parkinson’s disease(PD) patients,bu......
BACKGROUND: To summarize the metabolic pathway of 1-methyl-4-phenyl-1,2,3,6-tetradropyridine (MPTP) and its mechanism in......
One of the strategies of treating Parkinson’s disease(PD) is the replacement of lost neurons in the substantia nigra wi......
Identification of a 12.5-kD Protein From Caudate-Putamen Nucleus as a Dopaminergic Neuronotrophic Fa
The effect of the extract from caudate-putamen nucleus of newborn rats(CPe)on thedopaminergic(DA)neurons has been studie......
Intravenous administration of l-stepholidine (SPD), a dopamine (DA) receptor antagonist, in-creased the firing rate of ......
Molycorp,Inc.announced on August 12 that it has reached an agreement with Hitachi Metals to supply the company with rare......
Summary: To observe the effects of heterograft of glomus cells of carotid body on hemiparkinsonian rat models, rats wit......
The work is to explore the relationship between the levels of cytokines(IL-1β and IL-6)in C57BL/6J micetreated with MP......
Neuroprotective mechanism of modafinil on Parkinson disease induced by 1-methyl-4-phenyl-1,2,3,6-tet
AIM: To observe the neuroprotective mechanism of modafinil on Parkinson disease (PD) models induced by 1- methyl-4-pheny......
帕金森病是一种常见的中枢神经系统进行性退行性病变,其病因机制尚未明确,且缺乏令人满意的治疗方法。因此,建立有效的帕金森病模......
Objective: To explore the protective effect of minocycline on the apoptosis of cellular parkinsonism models induced by M......
Expression of gamma-aminobutyric acid A receptor subunits aα_1,β_1,γ_2 mRNA in rats with hepatic enc
AIM:To investigate the mRNA expression of gamma-aminobutyric acid A (GABAA) receptor subunits α1,β1,γ2 in different p......
Background Paraquat (PQ; 1,1’-dimethyl-4,4’-bipyridinium), a widely used herbicide that is structurally similar to the......
Neuroimaging is known to complement clinical findings in the diagnostic work u p of parkinsonian syndromes. Recently, tr......
BACKGROUND: Previous researches suggested that expression level of calbindin D28K mRNA decreased in substantia nigra (SN......
Neuronal quantity and ultrastructure in extracorticospinal tract of newborn rabbits with cerebral pa
BACKGROUND: The liver enzyme system and blood brain barrier function of newborn rabbits are incomplete. High level of bi......
BACKGROUND: Insulin receptor (IR) expression in the substantia nigra of patients with Parkinson disease (PD) is not only......
Analysis of brain-stem auditory evoked potential and visual evoked potential in patients with Parkin
BACKGROUND: With the development of neuroelectrophysiology, it had been identified that all kinds of evoked potentials m......
Biomarkers are very important indicators of normal and abnormal biological processes. Specific changes in pathologies, ......
Feasibility of establishing model of Parkinson disease by injecting 6-hydroxydopamine at different p
BACKGROUND: Previous researches found that animal models with Parkinson disease (PD) could be established by injecting 6......
Parkinson disease(PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra. Although i......
目的研究鱼藤酮所致的帕金森病大鼠的脑内α-突触核蛋白(α-synuclein, ASN)分布。方法 Wistar大鼠随机分成两组,分别给予鱼藤酮和......
Parkinson’s disease is a neurodegenerative disordermainly caused by degeneration of the dopaminergicneurons in the sub......
Study of apoptosis pattern of dopaminergic neurons and neuroprotective effect of nicotine in MPTP mo
Objective: To investigate the apoptosis of dopaminergic neurons and the protective effect of nicotine in 1-methyl-4-phen......
Establishing motor disorder mouse models of Parkinson disease Comparison of 6-hydroxydompamine and 1
BACKGROUND: At present,pathogenesis and mechanism of Parkinson disease (PD) are still unclear. Animal models of PD are e......
Intrastriatal glial cell line-derived neurotrophic factors for protecting dopaminergic neurons in th
BACKGROUND:Substantia nigra is deep in position and limited in range,the glial cell line-derived neurotrophic factor(GDN......
ATP敏感性钾通道已被证实广泛分布于血管平滑肌、心肌、胰腺等组织,发挥着诸如血管舒张、心肌缺血的保护及胰岛素分泌等作用。本综......
Neuroprotective effects of subthalamic nucleus high-frequency stimulation on substantia nigra neuron
BACKGROUND:Deep-brain stimulation has proven to be beneficial in the treatment of Parkinson’s disease(PD) patients.OBJE......
Parkinson’s disease(PD) is a chronic,progressive neurodegenerative central nervous system disease which occurs in the s......
BACKGROUND: Cellular adhesion molecule mediates the effects of glial cell line-derived neurotrophic factor in dopaminerg......
Changes in firing rate and firing pattern of midbrain dopaminergic neurons after lesioning of the do
Objective To study the effect of serotonergic efferent projection of the dorsal raphe nucleus(DRN)on the activity of sub......
Differential protein expression in substantia nigra induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahyd
BACKGROUND: To date, a complete protein expression profile of the midbrain substantia nigra in a mouse model of chronic ......
Effects of D2 receptor antagonist haloperidol on hippocampal neuronal apoptosis in a rat model of te
BACKGROUND: Dopamine receptors are divided into D1 and D2 subgroups. It has been reported that D2 receptors resist neura......
BACKGROUND: Subthalamic nucleus-high frequency stimulation (STN-HFS) plays an importantrole in the treatment of Parkins......
Protective effect of bone marrow-derived mesenchymal stem cells on dopaminergic neurons against 1-me
BACKGROUND: To date, the use of bone marrow-derived mesenchymal stem cells (MSCs) for the treatment of Parkinson’s dise......
BACKGROUND:Severe injury to dopaminergic neuronal cell bodies and their axon terminals in the substantia nigra pars comp......
Distribution of nitric oxide synthase positive neurons in the substantia nigra of rats with liver ci
BACKGROUND: Nitrogen monoxide plays an important role in the physiological activity and pathological process of striatum......
Objective To study the changes in neuronal activity of the zone incerta(ZI)following the unilateral lesion of the nigros......
