p38相关论文
目的:（1）明确结肠癌细胞中ANP32A可调控p38/Akt信号通路影响人结肠癌细胞增殖。（2）验证健脾消癌方含药血清可通过调控ANP32A/p38/Akt信......
第一部分自然衰老对小鼠LOXL2表达水平及骨骼肌结构和功能的影响目的赖氨酰氧化酶样蛋白2（LOXL2）是一种铜依赖性单胺氧化酶,其功能是......
目的:探讨甘露醇与神经干细胞增殖之间的关系及其可能机制,以期为甘露醇临床安全使用提供新的理论依据。方法:1)体外分离并培养小......
背景:胶质母细胞瘤（GBM）是一种极为致命的中枢神经系统肿瘤。目前临床仍以手术切除结合放疗、化疗等治疗方式为主。尽管近年来免疫疗......
目的:探讨8周跑台运动对db/dbT2DM小鼠认知功能的影响及其分子机制.方法:24只8周龄db/dbT2DM小鼠和8只同龄对照m/m小鼠,将db/db小......
目的 探讨泽漆水提物对LPS诱导的急性肺损伤(ALI)炎症因子TNF-α、IL-1β、IL-6及蛋白JNK、p38、ERK1/2的影响.方法 采用血清药理......
目的:颅内动脉瘤是常见的脑血管疾病之一,其破裂可引起颅内出血,对患者生命健康造成严重危害。目前认为,复杂的血流动力学所致血管......
目的 研究三焦祛湿方对阳离子化牛血清白蛋白(cationic bovine serum albumin,C-BSA)诱导的膜性肾病(membranous nephropathy,MN)......
目的:氟在自然界中广泛存在,适量摄入氟可以保持牙齿和骨骼的硬度,维持各系统正常功能,但长期过量地摄入氟会导致机体表现出氟斑牙......
目的:本研究旨在探讨TMEM16F调控P38/JNK信号通路介导神经元凋亡在阿尔茨海默病（Alzheimer’s disease,AD）中的作用机制。研究方法:1......
目的:构建RNA干扰真核表达载体,观察其对大鼠肾上腺嗜铬细胞瘤（PC12细胞）中CaMKIIβ基因的抑制作用。方法:设计并合成针对CaMKIIβ基......
目的 探讨P38丝裂原活化蛋白激酶(P38?MAPK)抑制剂对大鼠缺血再灌注脑组织基质金属蛋白酶-9(MMP-9)蛋白表达的影响.方法 选择90只......
目的 观察白藜芦醇对脑缺血再灌注(I/R)大鼠JNK、P38和神经元凋亡的影响.方法 36只SD大鼠随机分为:假手术组,I/R组,Res组[40 mg/(k......
目的探讨DNA损伤应答蛋白1 （regulated in development and DNA damage responses-1,REDD1）在幽门螺杆菌（Helicobacter pylori,H.pylo......
期刊
目的:神经病理性疼痛（NPP）是由躯体感觉神经系统的损伤或功能改变引起的退行性病变,背根神经节（DRG）感觉神经元产物-脊髓背根神经节神......
目的 探讨复方万年青胶囊联合氟尿嘧啶注射液(5-FU)对胃癌荷瘤小鼠NF-kb p65/p38水平的影响及其免疫调节作用,为明确药效机制提供......
研究背景:脑胶质瘤是成人常见的原发性颅内肿瘤。胶质瘤,尤其是高级别胶质瘤患者,预后差,易复发,中位生存期仅有14.6个月,5年生存......
急性肝衰竭（ALF）是一种罕见而严重的疾病,威胁着人类的健康。肝移植是治疗ALF最有效的方法。然而,由于供体器官缺乏、价格高昂等因素......
目的:脑血管病是现阶段全世界范围内威胁人类健康,影响人类寿命的常见疾病之一。缺血性脑卒中（ischemic stroke,IS）是脑血管病中最常......
目的:肺癌,是当今世界最常见的恶性肿瘤。而非小细胞肺癌（Non-small Cell Lung Cancer,NSCLC）是肺癌最主要的病理类型,约占全部肺癌......
目的:通过大鼠坐骨神经压榨损伤模型,观察电针对坐骨神经功能及S100蛋白、MBP蛋白、p-p38蛋白的表达,坐骨神经形态学的变化以及髓......
Gonadotropin-releasing hormone positively regulates steroidogenesis via extracellular signal-regulat
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The increased stability of p16 mRNA in murine hematopoie tic stem cell after irradiation was mediate
Purpose: The present study was undertaken to examine the expression level of p16 mRNA in mouse hematopoietic stem cell a......
Inhibition of Hydrogen Sulfide-Induced Angiogenesis and Inflammation in Vascular Endothelial Cells:P
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目的(1)研究藤黄酸在抑制破骨细胞分化成熟过程中的分子生物学机制；(2)将藤黄酸应用于破骨细胞相关的骨溶解疾病动物模型-OVX模型，在......
Inhibitoryeffectsofadenovirus-mediatedsiRNAtargetingp38ontitaniumparticle-inducedosteoclas
Osteoclastogenesisinducedbyparticleswornfromthesurfaceoftheimplantedprosthesisisoneofthemostcommonfactorscontributingtop......
Mechanistic roles of osteopontin in the osteogenic stimulation in the Thoracic ligament flavum cells
Background:Ossification of the ligamentum flavum (OLF) and related osteogenic mechanisms have been studied for many year......
Paris saponin Ⅶ suppresses osteosarcoma cell migration and invasion by inhibiting MMP-2/9 production
Metastasis is the primary cause of mortality in osteosarcoma.Targeting metastasis is a major strategy in osteosarcoma tr......
p-Hydroxylcinnamaldehyde reverses the resistance to TRAIL in human esophageal squamous cell carcinom
目的 Tumor necrosis factor-related apoptosis-inducing ligand(TRAIL),belongs to thetumor necrosis factor family and induc......
目的 TIPE3(Tumour necrosis factor alpha-induced protein 8-like 3)与肿瘤的发生发展密切相关,但其在人脑胶质母细胞瘤(GBM)中......
The regulation of phosphorylation of large-conductance,calcium-activated potassium channels in a rat
Background:Trigeminal neuralgia is a disorder of paroxysmal and severely disabling facial pain and continues to be a rea......
Aim To assess therapeutic effect and mechanism of Oxytropisfalcata Bung gel compound (OFBGC) in rats.Methods Wistar rats......
Involvement of group Ⅰ mGluRs in the activation of p38 MAPK in spinal cord Induced by peripheral for
MAPKs are a family of important intracellular signaling molecules that transduce extracellular stimuli into intracellula......
Calcitonin gene-related peptide increases proliferation of human umbilical vein endothelial cells by
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目的：探讨青蒿素(Artemisinin,ART)对过氧化氢(H202)诱导的氧化损伤的保护作用及其作用的机制。方法：建立过氧化氢诱导的RGC-5细胞氧......
背景 分泌型蛋白斯钙素(Stanniocalcin,STC)在鱼类中参与调节钙磷平衡.人类STC包含STC1和STC2两个成员,均和多种肿瘤有关.RAS转化......
目的：检测乳铁蛋白(Lactoferrin,LF)作用后人牙周膜细胞内MAPK信号通路相关蛋白ERK1/2以及p38的变化。方法：原代培养并鉴定人牙周膜......
目的 探讨木材燃烧烟雾颗粒物(wood smoke particles,WSP)对人原代呼吸道上皮细胞IL-8基因表达的影响及机制.方法 采集人呼吸道原......
Chemopreventive efficacy of menthol on carcinogen-induced cutaneum carcinoma through inhibition of i
Inflammation and oxidative stress have been implicated in various pathological processes including skin tumorigenesis.Sk......
Tumor necrosis factor alpha (TNFα) induced mouse fibrosarcoma L929 cell necroptosis by inhibiting p3
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Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma
The cyclic AMP (cAMP) signaling pathway has been reported to either promote or suppress cell death,in a cell context-dep......
p38 as a member of MAPK family,has been conversed from yeast to mammals.It has been implicated in numerous biological pr......
目的探讨山奈酚逆转耐多柔比星（ADM）的慢性粒细胞白血病K562/ADM细胞耐药性及相关机制。方法采用四甲基偶氮唑盐（MTT）法检测ADM作用24 ......
目的探讨乙型肝炎病毒x(HBx)蛋白对人肝癌细胞增殖的分子作用机制。方法构建HBx蛋白的绿色荧光蛋白真核表达载体HBx-pEGFP-C1，利用......
