heparanase相关论文
Gubenyiliu Ⅱ inhibits breast tumor growth and metastasis associated with decreased heparanase expres
OBJECTIVE Gubenyiliu Ⅱ (GY Ⅱ), a traditional Chinese medicine (TCM) formula used in our hospital, has shown beneficial......
目的研究类乙酰肝素酶(heparanase,HPSE)与人类自然流产的关系,进一步探讨HPSE在妊娠过程中所起的作用。方法采用免疫荧光染色法和......
Contribution of elF-4E inhibition to the expression and activity of heparanase in human colon adenoc
AIM:Heparanase degrades heparan sulfate proteoglycans(HSPGs) and is a critical mediator of tumor metastasis andangiogen......
目的 研究正、反义人Heparanase基因对肝癌细胞转移潜能的影响。方法 将正、反义人 Heparanase 基因稳定转染肝癌细胞系HepG2,半定......
AIM:To explore the expression of heparanase mRNA andpoint mutation in hepatocellular carcinoma(HCC).METHODS:Reverse tra......
近年研究发现内切糖苷酶(Heparanase)[1,2]与肿瘤转移的关系密切,而转移是肝癌的重要特点[3],为此我们应用半定量RT-PCR检测7例正......
腺样囊性癌、前列腺癌等肿瘤的嗜神经浸润性与其局部复发、转移和预后关系密切[1,2 ] 。肿瘤的嗜神经浸润(perineuralinvasiveness......
Expression of heparanase mRNA in anti-sense oligonucleotide-transfected human esophageal cancer EC97
AIM: To investigate the effects of anti-sense oligonudeotides (ASODNs) on mRNA expression of heparanase in human esophag......
乙酰肝素酶(heparanase,HPA)是目前研究中发现的唯一一种能够切割细胞外基质中硫酸肝素蛋白多糖侧链的内源性糖苷酶。HPA可促进肿......
Heparanase antisense oligodeoxynucleotide inhibits angiogenesis and metastasis of human mammary carc
Objective:To evaluate the inhibitory effect of heparanase antisense oligodeoxynucleotide(AS-ODN) on the angiogenesis and......
目的探讨乙酰肝素酶(heparanase,HPSE)和蛋白聚糖1(syndecan-1)在人类早期复发性自然流产绒毛组织中的表达及两者与复发性自然流产......
目的探讨肝素对脓毒症肝损伤小鼠体内肝素酶（HPA）表达的影响。方法6~8周龄健康雄性C57BL/6小鼠48只，按照随机数字表法将动物分组。24......
Expression of heparanase mRNA in anti-sense oligonucleotide-transfected human esophageal cancer EC97
AIM: To investigate the effects of anti-sense oligonucleotides (ASODNs) on mRNA expression of heparanase in human esopha......
AIM: To explore the relation between heparanase (HPA)and nm23-H1 in hepatocellular carcinoma (HCC), and whether they cou......
Heparanase expression,degradation of basement membrane and low degree of infiltration by immunocytes
AIM: To disclose the mechanisms that accelerate or limit tumor invasion and metastasis in gastric cancer patients.METHOD......
The effects of targeted silencing of heparanase gene by small interfering RNA (siRNA) on invasiveness and metastasis of ......
目的 预测并鉴定新的人乙酰肝素酶(Hpa)抗原的HLA-A2限制性CTL表位,为恶性肿瘤多肽疫苗的免疫治疗提供依据. 方法 采用SYFPEITHI和......
目的 探讨自行研制的肝素酶多肽抗体对人肝癌HCCLM6细胞生长和侵袭的影响.方法 采用二苯基溴化四氮唑蓝(MTT)法检测细胞生长曲线,......
Heparanase antisense oligodeoxynucleotide inhibits angiogenesis and metastasis of human mammary carc
Objective:To evaluate the inhibitory effect of heparanase antisense oligodeoxynucleotide(AS-ODN) on the angiogenesis and......
Intestinal anti-inflammatory activity of Ground Cherry(Physalis angulata L.) standardized CO_2 phyto
AIM To investigate the effects of Ground Cherry(Physalis angulata L.)standardized supercritical CO_2 extract in trinitro......
Identification of Human Serum Protein Targets of Qianggu Decoction(强骨饮) in Primary Type Ⅰ Osteoporos
Objective: To investigate the serum protein targets of Qianggu Decoction(强骨饮, QGD) on treating osteoporosis by the pr......
Objective An organic layer prepared from the cortex of Morus alba(Moraceae)was studied in order to identify the active c......
目的探讨槲皮素对宫颈癌侵袭和转移的作用机制及其与乙酰肝素酶(heparanase,HPA)的相关性。方法构建宫颈癌Hela细胞组、Hela+槲皮......
目的近期研究显示,Syndecan-1和乙酰肝素酶(heparanase,HPA-1)可能参与多种恶性肿瘤的侵袭和转移,但关于两者与皮肤鳞状细胞癌(cut......
Clinicopathological significance of heparanase and basic fibroblast growth factor expression in huma
AIM: Human heparanase is an endo-D-glucuronidase that degrades heparan sulfate/heparin and has been implicated in a vari......
AIM: To explore the relation between heparanase (HPA) and nm23-H1 in hepatocellular carcinoma (HCC), and whether they co......
Objective: To explore the expression and significance of heparanase in non-small cell lung cancer (NSCLC) regarding prog......
Tumor metastasis and the reciprocal regulation of heparanase gene expression by nuclear factor kappa
AIM: To investigate whether NF-kB is activated in human gastric carcinoma tissues and, if so, to study whether there is ......
OBJECTIVE: To discuss the mechanism of Yiqiyangyin recipe in rats with adriamycin (ADR)-induced nephropathy. METHODS: We......
OBJECTIVE To screen metastatic-related genes in human gastric cancer by a low-density cDNA microarray technique. METHODS......
目的:探讨乙酰肝素酶(heparanase,HPA)及缺氧诱导因子-1α(hypoxia inducible factors-1α,HIF-1α)在食管鳞癌中的表达及其与食管......
Heparanase expression,degradation of basement membrane and low degree of infi ltration by immunocyte
AIM: To disclose the mechanisms that accelerate or limit tumor invasion and metastasis in gastric cancer patients. METHO......
GubenyiliuⅡ inhibits breast tumor growth and metastasis associated with decreased heparanase express
OBJECTIVE GubenyiliuⅡ(GYⅡ),a traditional Chinese medicine(TCM)formula used in our hospital,has shown beneficial effect......
乙酰肝素酶(heparanase,HPSE-1)是哺乳动物细胞分泌的一种内切糖苷酶,在恶性肿瘤的进展过程中发挥着重要作用。作为促进肿瘤进展的......
肿瘤的侵袭转移是导致肿瘤患者死亡的主要原因,寻找引发肿瘤细胞侵袭与转移的因素并进行有效阻断是治疗肿瘤的重要方法之一。肿瘤......
AIM:To develop short hairpin RNA(shRNA)against heparanase,and to determine its effects on heparanase expression and the ......
Background and objective Heparanase has been thought to be a good molecular marker of tumor,and the heparanase expressio......
目的探讨肝素酶(heparanase,Hpa)、碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)在卵巢癌组织中的表达及与卵巢......
目的研究长梗秦艽酮体外抗肿瘤活性,探讨其部分作用机制。方法采用噻唑蓝(MTT)法观察长梗秦艽酮对BEL-7402,HeLa,BXPC-3,PANC-1细......
Effects of small interfering RNA targeting heparanase-1 combined with heparin on invasiveness of mou
Background and Objective:Heparanase-1 (HPA-1) can promote angiogenesis and metastasis of malignant tumors and plays an i......
Heparan sulphate proteoglycans (HSPGs) consist of a core protein and several heparan sulphate (HS) side chains covalentl......
乙酰肝素酶(heparanase,HPA)在胃癌的发生、发展及其血管形成中起重要作用。笔者就HPA的分子结构特点、在胃癌中的表达及其在促进......
目的:探讨Hps(heparanase,乙酰肝素酶)和bFGF(basic fibroblast growth factor,碱性成纤维细胞生长因子)与宫颈癌发生、发展及预后......
糖胺聚糖(glycosaminoglycan,GAG)是一类含有糖醛酸和氨基糖残基的重要生物大分子。在细胞表面和细胞外基质中存在着一些高亲和力......
