disulfiram相关论文
Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer vi
...
Developing chemotherapy drugs with high efficacy and few side effects has been a bottleneck problem that requires an eff......
Sepsis is a dysregulated immune response to infection and potentially leads to life-threatening organ dysfunction,which ......
In situ triggering antitumor efficacy of alcohol-abuse drug disulfiram through Cu-based metal-organi
Although approved as an alcohol-abuse drug,disulfiram(DSF)exhibited potential anticancer activity when chelated with cop......
Cytotoxic effects of Disulfiram/copper complex on human myeloma cells by induction and activation of
Objective Background: Disulfiram(DSF),a member of the dithiocarbamate family,is a re-purposing drug that has previously ......
Comparative pharmacokinetics of disulfiram5-loaded microsphere and disulfiram-solution in Beagle dog
Objective Disulfiram,a dealcoholic drug,shows promise as an anticancer drug.Because ofits low bioavailability and poor s......
1例60岁男性饮酒期间突发右侧肢体无力和意识障碍,约1 h后就诊于首都医科大学宣武医院急诊科,血压70/40 mmHg(1 mm Hg=0.133 kPa),......
1例81岁女性患者因肺部感染给予头孢西丁2 g静脉滴注。输注结束后1.5 h，患者因咳嗽自行服用复方甘草口服溶液10 ml，约10 min后出现胸......
1例77岁女性患者行腹腔镜左肾恶性肿瘤根治性切除术。术前30 min给予头孢哌酮钠他唑巴坦钠2 g静脉滴注，术中给予氢化可的松注射液40......
Exploring alternative biomedical use of traditional drugs in different disease models is highly important as it can redu......
...
The role of interleukin-18 in glioblastoma pathology implies therapeutic potential of two old drugs-
Based on reporting in the last several years, an impressive but dismal list of cytotoxic chemotherapies that fail to pro......
考察了抗白内障药双硫伦乳剂中双硫伦的化学稳定性，测定了不同的乳剂组成对双硫伦化学稳定性的影响，得出双硫伦降解服从一级反应，速率......
目的制备双硫伦(DSF)包合物滴眼剂.方法将DSF与HP-β-CD作用形成包合物,再制成滴眼剂.采用HPLC法测定DSF的含量.结果 DSF包合物滴......
目的 测定双硫仑-羟丙基-β-环糊精（DSF-β-CDHP）的包合常数；研究包合物形成的热力学性质。方法 采用RP-HPLC法。测定溶液中双硫仑含......
采用高效液相色谱法和液相色谱／质谱联用法对双硫仑在溶液中的化学稳定性进行了考察，采用氢化可的松作为内标物，对双硫仑进行定量。方......
目的制备以羟丙基β环糊精为传递系统的双硫伦眼用制剂.通过药物环糊精包合物的形成,改善双硫伦的溶解性、眼角膜透过性及生物利用......
双硫仑作为一种治疗慢性酒精中毒的药物在临床中广泛使用。近几十年研究发现它除了戒酒作用还在治疗癌症中具有巨大潜力,针对它在......
目的为进一步了解Disulfiram（DS）及DS联合Cu（DS/Cu）对急性淋巴细胞白血病Molt4细胞增殖、凋亡及多药耐药1（MDR1）基因水平表达的影响。方......
目的为进一步了解Disulfiram（DS）及DS联合Cu（DS/Cu）对急性淋巴细胞白血病Molt4细胞增殖、凋亡及多药耐药1（MDR1）基因水平表达的影响。方......
Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy： Is there still a
四乙秋兰姆化二硫和钙 carbimide 是二白酒威慑然而，广泛地在那里在酒精中毒治疗使用的狂言存在对他们的安全的大担心。hepatotoxic......
The role of interleukin-18 in glioblastoma pathology implies therapeutic potential of two old drugs~
Based on reporting in the last several years,an impressive but dismal list of cytotoxic chemotherapies that fail to prol......
目的探讨头孢菌素致双硫仑样反应的临床表现、治疗及预防要点。方法对60例头孢菌素致双硫仑样反应患者的临床表现及治疗进行回顾性......
Objective: Aldehyde dehydrogenase (ALDH) enzymatic activity identifies ovarian cancer stem-like cells. We investigated t......
The chronic toxicological profile of disulfiram/copper gluconate (DSF/CG) combination was investigated in a 90 day time ......
The chronic toxicological profile of disulfiram/copper gluconate (DSF/CG) combination was investigated in a 90 day time ......
Toxicological Evaluation of Disulfiram, Copper Gluconate and Disulfiram/Copper Gluconate Combination
This research work investigated and compared the chronic renal toxicological profile of disulfiram, copper gluconate and......
Toxicological Evaluation of Disulfiram, Copper Gluconate and Disulfiram/Copper Gluconate Combination
This research work investigated and compared the chronic renal toxicological profile of disulfiram, copper gluconate and......
Substance use disorders(SUDs)are a growing problem among older adults.Acamprosate,disulfiram,and naltrexone are United S......
目的研究disulfiram（DS）联合Cu（DS/Cu）对耐药白血病细胞株HL60/ADM的逆转耐药作用及与JNK通路的关系。方法MTT法检测DS/Cu对HL60/ADM细......
期刊
Despite leadership by dedicated lay organization and patient-based advocacy groups, the way forward for prospective cand......
This article describes the prototypical clinical presentation, electrodiagnostic and neuropathological findings and trea......
To improve the corneal permeability and water-solubility of disulfiram(DSF), which is an ocular drug for cataract, P188 ......
Disulfiram remains a viable option as a treatment for alcohol dependence and has been shown in recent studies to be succ......
背景：急性髓细胞白血病(Acute Myeloid Leukemia, AML)是一种在形态学、遗传学及表观遗传学上具有异质性的疾病,主要特点是原始及幼......
背景急性淋巴细胞白血病(ALL)和非霍奇金淋巴瘤(NHL)是血液系统恶性肿瘤中较为常见的疾病,其中T-ALL由于其易对髓外组织和器官的浸......
背景急性白血病(AL)是我国十大恶性肿瘤之一,是青少年和35岁以下成年人发病率最高的恶性肿瘤；近年来随着室内外环境污染等因素的影......
研究背景近几十年来,由于子宫内膜癌呈现世界性的高发病率,其死亡人数高于同期卵巢癌及宫颈癌患者,使得研究界及医疗界对子宫内膜......
背景Burkitt’s淋巴瘤是一种侵袭性B细胞非霍奇金淋巴瘤,疾病进展快,死亡率高。虽然随着化疗及免疫治疗等研究的进展,Burkitt’s淋......
研究背景：急性髓细胞白血病(Acute Myeloid Leukemia, AML)是一种异质性疾病,随着化疗方案的改进,其缓解率不断提高,但难治和复发仍......
