cocaine相关论文
Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behavior
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Aim: To investigate the effect of cocaine on apoptosis and caspase-3 activity in germ cells in male rats at different ag......
Oscillatory firing is an important process in neural system for presenting, integrating and synchronizing neuronal signa......
Caloric diet,such as fat and sugar,has rewarding effects.Excessive consumption of caloric food has been indicated to aff......
Adolescent exposures to cocaine increase anxiety-like behavior and induce morphological and neuroche
Objective In humans,experiencing drugs of abuse during adolescence increases the risk of psychiatric disorders and drug ......
The development of cocaine addiction involves long-lasting changes in neural plasticity and histone modification has bee......
Ovarian hormone-dependent changes in cocaine-induced dopamine neuron activities that is associated w
Clinical and experimental evidences have indicated that females appear to be more vulnerable than males to the reinforci......
Neuroimaging studies using positron emission tomo graphy suggest that reduced dopamine (DA) D2 receptor (D2R)availabilit......
Vav2 regulates dopamine transporter-dependent mesolimbic dopamine homeostasis and behavioral respons
Dopamine (DA) homeostasis is essential for a variety of brain activities.Dopamine transporter (DAT)-mediated DA reuptake......
THE INFLUENCE OF ADOLESCENT COCAINE EXPOSURE ON PSYCHIATRIC BEHAVIORS IN ADULT ANIMALS: A PRELIMINAR
In humans,substances use during adolescence increases the risk of psychiatric disorders and drug addiction in adulthood.......
Blockade of HCN channels in nucleus accumbens cholinergic neurons preventscue-inducedrelapse of coca
OBJECTIVE To study the relationship between HCN channels of nucleus accumbens(NAc)cholinergic interneurons(CINs)and addi......
Dopamine(DA)homeostasis is essential for a variety of brain activities.Dopamine transporter(DAT)-mediated DA reuptake is......
Cocaine Protracted Withdrawal Produces Circadian Rhythmic Alterations of p-GSK-31β in Reward-related
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Microfluidic paper-based analytical devices(μPADs)represent a growing class of low-cost,user-friendly and disposable te......
Microfluidic paper-based analytical devices(μPADs)represent a growing class of low-cost,user-friendly and disposable te......
Substances of abuse(SoA),as well as smoking and alcohol consumption,are well known for their impact on male fertility st......
Single Exposure to Cocaine Impairs Reinforcement Learning by Potentiating the Activity of Neurons in
Plasticity in the glutamatergic synapses on striatal medium spiny neurons (MSNs) is not only essential for behavioral ad......
Drug-Seeking Behavior Is Significantly Attenuated in Nutritionally Supplemented Cocaine Withdrawn Sp
<b>Aim:</b> The effect of patented nutritional supplementation on drug-seeking behavior in cocaine addicted rats during ......
A simple and fast HPLC analysis method for cocaine HCl in cocaine sample was developed. In this work, cocaine in sample ......
目的 研究褪黑素拮抗大鼠可卡因诱导的条件性位置偏爱的作用和可能机制.方法 建立可卡因诱导的条件性位置偏爱模型,诱导前30min给......
目的:探讨脑源性神经营养因子(BDNF)是否作为核因子NF-κB的靶基因,参与NF-κB对可卡因行为敏化的影响.方法:建立NF-κB抑制剂DDTC......
目的:探讨2,4-二羟基二苯甲酮(2,4-dihydroxybenzophenone,BP-1)对可卡因致小鼠脑中多巴胺、5-羟色胺、谷氨酸和γ-氨基丁酸含量变......
目的采用超高效液相色谱-质谱联用方法同时测定复方甘草口服溶液中吗啡、可待因、罂粟碱和可卡因的含量。方法采用Waters BEH C18(......
Aim: Clonidine is an α2 adrenoceptor agonist that is frequently used to reduce withdrawal symptoms during opioid detoxi......
,Inhibitory role of oxytocin in psychostimulantinduced psychological dependence and its effects on d
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Cocaine is one of the most abused illicit drugs worldwide.It is well known that the dopamine (DA) transporter is its maj......
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目的运用系统综述方法评价光遗传技术在可卡因成瘾机制中的应用。方法以"光遗传技术"、"成瘾"、"可卡因"等为关键词，通过检索中国期......
Background Cocaine addiction may involve complex neuroadaptations, including many changes of genes expression.Dopamine D......
Differences in cocaine-induced place preference persistence, locomotion and social behaviors between
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
长效阿片受体激动剂美沙酮对阿片依赖的有效治疗提示,慢启动长效多巴胺受体(DAT)抑制剂很可能对精神兴奋剂成瘾具有潜在治疗作用。......
期刊
Background Cocaine addiction may involve complex neuroadaptations, including many changes of genes expression.Dopamine D......
探讨妊娠期给予可卡因对母体和胎儿的影响.妊娠小鼠分为3组:可卡因注射组(每日两次注射盐酸可卡因10 mg/kg, COC); 盐水对照组(每......
G蛋白耦联受体激酶5(GRK5)在G蛋白耦联受体信号转导中起重要调节作用.本文研究了单次给予成瘾性药物吗啡、海洛因和可卡因对大鼠脑......
建立了尿样中可卡因（COC）及其代谢物爱冈宁甲基酯（EME）的气相色谱检测方法。采用液液萃取法提取尿样中可卡因和爱冈宁甲基酯,考察了萃......
就近些年来阿片类、苯丙胺类、可卡因类依赖性药物的化学结构、特性、代谢产物及其对人体危害的研究进行了综述.......
目的:研究异丙酚对可卡因抑制PC12神经细胞增殖的细胞毒性的影响.方法:应用噻唑蓝(MTT)比色法测定不同浓度可卡因对PC12细胞增殖的......
目的:探讨不同剂量的左旋四氢巴马汀(1-THP)对可卡因引起的条件性位置偏爱的影响以及自身是否引起条件性位置偏爱.方法:采用倾向性......
目的：探讨1,3-二苯-1,3-丙二酮（DPPD）对可卡因致小鼠急性肝损伤及神经毒性的保护作用。方法：可卡因急性肝损伤模型采用♂C57BL/6N小鼠,......
目的獉獉：探讨脑源性神经营养因子（BDNF）是否作为核因子NF-κB的靶基因,参与NF-κB对可卡因行为敏化的影响。方法獉獉：建立NF-κB抑制......
在兔角膜表面置直径为９ｍｍ圆形４％可卡因滤纸片１０ｓ，９０ｓ，擦去松解上皮，保留角膜缘内２ｍｍ完整上皮区。手术后不同时间，用光镜及透射电镜观察４％可卡因对角膜的......
采用乙醇热溶剂法合成了TiO2纳米带，将所合成的TiO2纳米带与可卡因适体和壳聚糖混合后修饰到玻碳电极上，研制了一种新型的适体传感器......
目的建立妊娠中晚期接触可卡因的小鼠动物模型,探讨脑功能的可塑性现象和机制.方法测量可卡因处理组与对照组仔代小鼠在青春期和成......
采用自组装法将带巯基的捕获DNA探针固定到金电极表面，利用杂交反应将可卡因适体固定到电极上制得可卡因适体传感器．以钌联吡啶为电......
目的：观察可卡因对痛阈和LHb痛相关神经元放电的影响。方法：皮下注射不同剂量可卡因，观察大鼠痛阈的变化；用玻璃微电极记录静脉注射可......
目的：探讨可卡因对外侧缰核神经元的作用及可能机制。方法：腹腔注射可卡因，观察内、外侧缰核神经元c—Fos蛋白的表达；在外侧缰核微电泳......
本文采用水热法合成了硫化铅量子点,将其与壳聚糖混合后修饰在玻碳电极上,利用PbS与巯基之间的强烈的键和作用,直接将所合成的带巯......
