PRODRUG相关论文
Various boron-containing drugs have been approved for clinical use over the past two de-cades,and more are currently in ......
A lipophilic prodrug of Danshensu: preparation, characterization, and in vitro and in vivo evaluatio
Danshensu [3-(3,4-dihydroxyphenyl) lactic acid,DSS],one of the significant cardioprotective components,is extracted from......
A simple Paclitaxel (PTX) prodrug based on TPGS and disulfide bond (TPGS-S-S-PTX) was synthesized by a two step esterifi......
Conventional cancer chemotherapy often fails to improve patient mortality and morbidity due to its overwhelming systemic......
Dual pH-responsive 5-aminolevulinic acid supramolecular prodrug micelles for enhanced photodynamic a
Photodynamic therapy (PDT) is a promising modality for the treatment of cancer and many other diseases[1].5-Aminolevulin......
An ideal cancer therapy is to eliminate cancer cells with least damage to normal cells.Monomethyl auristatin E (MMAE),an......
Redox-activatable hyaluronic acid-SS-mertansine prodrug:superior drug loading,enhanced toleration,an
Polymer-drug conjugates,a novel nanoscale drug delivery system,have achieved fantastic developments over the decades[1].......
Nowadays the development of polymeric prodrug,which convert drug into an inactive but stable polymer-drug conjugates and......
Photodynamic therapy(PDT)has recently been extensively explored as a promising approach for precise localization and the......
Chemotherapy is one of the most promising therapeutic strategies in oncology,but the poisonous side effect and lack of t......
Design platinum (Ⅳ) prodrugs of cisplatin and oxaliplatin with long lipid chains for drug delivery a
Drug resistance,both inherent and acquired,is a major drawback and the main reason for the failure of Pt drugs[1].To ove......
Nanoscale drug delivery systems could endow the antitumor agents with passive and active targeting ability[1].However,th......
Redox-Sensitive Micelles Based on PEG-Methotrexate Prodrug with Different Hydrophilic/Hydrophobic Ba
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Simultaneous Inhibition of Epidural Fibrosis and Arachnoiditis to Reduce Failed Back Surgery Syndrom
Failed back surgery syndrome(FBSS) refers to postoperative functional incapacity and pain,mainly caused by epidural fibr......
SL-01,dodecyl-3-((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidi......
MEK1/2 kinase inhibitors have exhibited great potency in treatment of many cancer types in which activating mutations of......
Nanocarriers delivering prodrugs are important strategies to improve the in vivo effectiveness and efficiency.For therap......
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Biocompatible polymeric nanocomplexes as an intracellular stimuli-sensitive prodrug for type-2 diabe
Combination therapy is usually considered as a promising strategy owing to its advantages such as reduced doses, minimiz......
Pharmacokinetics in rats and in vitro Species difference in hydrolysis of a novel nitric dioxide don
ZJM-289, a novel nitric oxide-donating derivative of 3-n-butylphthalide, has been reported to alleviate cerebral ischemi......
Intestinal OCTN2 transporter as a target for enhanced oral delivery for small-molecule prodrug and L
The organic cation/camitine transporter (OCTN2) is a high affinity cation/carnitine transporter widely expressed in huma......
Somatostatin receptor-mediated tumor-targeting drug delivery using octreotide-PEG-paclitaxel conjuga
Aims:A novel ligend-PEG-drug conjugate,octreotide-polyethene glycol-paclitaxel (OCT-PEG-PTX) was developed for efficient......
Synthesis of liguzinediol acetyl amino acid ester prodrugs and their biological evaluation as promis
The liguzinediol was a potential drug for the treatment of heart failure with high effect and low safety risk.However,in......
Aberrant epigenetic alterations of tumor suppressor genes have been recognized as a driving force in cancer.Histone deac......
Light-Promoted Lysosomal Escaping of a Monofunctional Pt(Ⅱ)Complex Bearing BODIPY-derived Chelator f
Being sequestered into cell lysosome is a large obstacle to reduce the side effects and improve the efficacy for platinu......
Small changes in the length of diselenide bond-containing linkages exert great influences on the ant
Homodimeric prodrug-based self-assembled nanoparticles,with carrier-free structure and ultrahigh drug loading,is drawing......
Identification of a new azoreductase driven prodrug from bardoxolone methyl and 5-aminosalicylate fo
For local treatment of ulcerative colitis,a new azoreductase driven prodrug CDDO-AZO from bardoxolone methyl(CDDO-Me)and......
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Organic carbon monoxide prodrug,BW-CO-111,in protection against chemically-induced gastric mucosal d
Metal-based carbon monoxide(CO)-releasing molecules have been shown to exert anti-inflammatory and anti-oxidative proper......
Chemotherapy is one of the commonly used methods to treat various types of cancers in clinic by virtue of its high effic......
为了提高鸟嘌呤核苷类似物的药代动力学和稳定性,设计合成了取代氨基修饰L-DdG和L-D4G的6位,得到一系列的前药,经NMR、MS、高分辨......
作为对环磷酰胺结构改造新思路的延续,本文以化合物9i为先导物设计并合成了三个系列环磷酰胺哌嗪季铵盐类衍生物(10,11和13).通过......
本文完成了一种新型紫杉醇-氮芥前药分子的合成及初步活性评价.化学模拟还原活化表明硝基还原后此前药可释放紫杉醇,并利用人胶质......
目的探索通过前药途径改善MG132稳定性和成药性的方法。方法基于前药设计原理,设计并合成5种MG132前药,通过体外模拟实验,即分别在......
目的:制备共轭亚油酸-吉西他滨共轭物脂质体(CGLP)并考察其相关性质。方法:通过正交设计筛选出CGLP的最优制备方法。采用激光纳米......
目的:本研究利用肝素前体K5多糖连接抗肿瘤药物阿霉素(doxorubicin,DOX)制备具有p H敏感特性的K5多糖-阿霉素前体药物(K5-DOX),并......
本文在对比中美两国对于前药专利侵权判定司法实践的基础上,分析了中美两国有关专利共同侵权和诱导侵权的判定规则,借鉴美国法院对......
目的研究地塞米松(Dex)高分子前药(P-Dex)对佐剂性关节炎(AIA)大鼠的疗效及其组织分布。方法于大鼠后足跖皮内注射完全弗氏佐剂建......
PEGylated prodrug, covalent attaching polyethylene glycol (PEG) polymer chains to therapeutic drugs, is one of the most ......
Aim:To evaluate the pharmacokinetic characteristics of L-valyl-ara-C,apeptidomimetic prodrug of ara-C.Methods:After the......
Phase Ⅰ study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treat
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BF211,a bufalin (BF) derivative,exhibits stronger anti-cancer activity than BF but with potential cardiotoxicity.Fibrobl......
Design and synthesis of selective sphingosine-1-phosphate receptor 1 agonists with increased phospho
FTY720 and IMMH002,prodrugs for sphingosine-1-phosphate receptor 1 (S1P1) agonists,show inadequate and inconsistent leve......
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为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Advances in Nucleotide Antiviral Development from Scientific Discovery to Clinical Applications:Teno
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
