NORCANTHARIDIN相关论文
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Induction of Apoptosis in Human Hep3B Hepatoma Cells by Norcantharidin through a p53 Independent Pat
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Objective:To observe the effect of norcantharidin (NCTD) on collagen-induced arthritis (CIA) rats.Methods:Sixty Sprague-......
Norcantharidin inhibits DNA replication and induces mitotic catastrophe by degrading initiation prot
Cdc6,an essential initiation protein for DNA replication,also participates in the ATR checkpoint pathway and plays a vit......
Preparation,in vitro release,pharmacokinetics and tissue distribution of norcantharidin loaded to po
Objective: We prepared the norcantharidin loaded into poly (MePEGcyanoacrylate-co-hexadecylcyanoacrylate) nanoparticles,......
Galactose-specific PEGylated PHDCA nanoparticles for active Norcantharidin delivery in hepatocellula
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Restrain Effect of Three Anti-tumor Monomers Extracted from Chinese Medicine on The Growth of ECV304
Objective: Melittin,norcantharidin and bufalin are three extracts from Chinese herbal medicine in clinical application w......
Development of a LC-MS/MS method for the determination of norcantharidin in beagle plasma and its ap
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Preparation,in vitro release,and pharmacokinetics of norcantharidin loaded to MePEG-PHDCA nanopartic
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An integrated proteomics and metabolomics strategy to uncover the anti-cancer mechanisms of norcanth
The proteome and metabolome are directly interconnected since protein levels affect the metabolic reprogramming and meta......
Mitogen -activated protein kinase-dependent apoptosis in norcan-tharidin-treated A375-S2 cells is pr
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Metal-organic framework IRMOFs coated with a temperaturesensitive gel delivering norcantharidin to t
BACKGROUND Norcantharidin(NCTD)is suitable for the treatment of primary liver cancer,especially early and middle primary......
目的:制备去甲斑蝥素白蛋白纳米粒,并考察其理化性质.方法:采用超高压微射流技术制备去甲斑蝥素白蛋白纳米粒,以白蛋白纳米粒的平......
目的 研究去甲斑蝥素对肺癌A549细胞株体外放射增敏作用及其可能存在的增敏机制.方法 肺癌A549细胞体外常规培养,通过不同的去甲斑......
目的 研究去甲斑蝥素( NCTD)对人类胆管癌细胞系QBC939的生长抑制作用,初步探讨其作用机制.方法将 NCTD作用于经体外培养的QBC939......
Inhibitory effect of norcantharidin on the grow th of human gallbladder carcinoma GBC-SD cells in vi
BACKGROUND: Gallbladder carcinoma is a lethal malignant neoplasm with dismal surgical results. Unfortunately, the adjuva......
目的:研究去甲斑蝥素(NCTD)通过抑制Hedgehog信号通路(SHH)关键调节因子及其下游转录因子SOX2对急性髓系白血病细胞增殖的影响.方......
目的 设计合成去甲斑蝥素酰胺类衍生物,并评价其抗肝癌活性.方法 以呋喃和顺丁烯二酸酐为起始原料,通过Diels-Alder反应成环,再经......
目的:制备叶酸修饰去甲斑蝥素隐形泡囊新型给药系统,并进行表征及体外药效学评价.方法:采用改良注入法制得新型给药系统,考察其形......
目的:观察去甲斑蝥素-N-乳糖酰壳聚糖/丝素蛋白微球(norcantharidin-N-chitosan-silk fibroinmicrospheres,NCTD-N-CS/SF-MS)其对......
目的观察连续给予去甲斑蝥素-壳聚糖缓释制剂(NCTD-CTS)和去甲斑蝥素(NCTD)对大鼠长期毒性的损伤表现、程度及可逆性,为进一步的实......
AIM: To investigate the mechanism of norcantharidin (NCTD)-induced HeLa cell apoptosis. METHODS: HeLa cell growth inhibi......
目的:探讨去甲斑蝥素抑制结肠癌细胞上皮-间质转化的分子机制,为中药抗癌机制的研究奠定基础.方法:将HT-29结肠癌细胞经NCTD处理后......
Preparation and Evaluation of Norcantharidin-encapsulated Liposomes Modified with a Novel CD19 Monoc
In this study,norcanthridin(NCTD)-encapsulated liposomes were modified with a novel murine anti-human CD19 monoclonal an......
Mitogen-activated protein kinase-dependent apoptosis in norcan-tharidin-treated A375-S2 cells is pro
Background We have reported that norcantharidin (NCTD) induces human melanoma A375-S2 cell apoptosis and that the activa......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
INTRODUCTION The antitumor activity of norcantharidin (NCTD),the demethylated analogue of cantharidin, was studied in th......
目的 观察去甲斑蝥素(NCTD)诱导肝癌细胞凋亡的分子学机制,为合理应用NCTD治疗肝细胞肝癌提供理论基础.方法 对肝癌细胞株SMMC-772......
Mitogen-activated protein kinase-dependent apoptosis in norcan-tharidin-treated A375-S2 cells is pro
Background We have reported that norcantharidin (NCTD) induces human melanoma A375-S2 cell apoptosis and that the activa......
AIM: To investigate the effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cel......
目的 研究去甲斑蝥素(NCTD)联合阿霉素(ADR)对多发性骨髓瘤细胞增殖、凋亡的影响及其机制.方法 以U266细胞为研究对象,采用NCTD(......
Objective The immunotoxins generated by conjugating monoclonal antibody (mAb) and a certain toxin play an important and ......
目的 研究去甲斑蝥素(NCTD)降低程序性细胞死亡因子4(PDCD4)表达的机制.方法 MTT法测定NCTD 5～640 μmol·L-1与人胃癌BGC-823细胞......
目的探讨去甲斑蝥素（norcantharidin,NCTD）和紫杉醇（paclitaxel,PTX）联合诱导白血病细胞K562凋亡的效应及机制。方法采用流式细胞术分......
目的观察比较去甲斑蝥素复方注射液联合CTOP（环磷酰胺＋吡喃阿霉素＋长春新碱＋强的松）方案化疗与单用CTOP方案化疗对非霍奇金淋巴瘤的疗效......
【目的】研究25种斑蝥素类化合物对小菜蛾胃毒活性的构效关系,为开发高效、易得的斑蝥素类杀虫剂提供依据。【方法】以斑蝥素（Ⅰ）为......
目的:探讨去甲斑蟊素对神经胶质瘤U87MG细胞生物学行为的影响。方法:用MTT法检测不同浓度的去甲斑蟊素对U87MG细胞增殖的抑制作用......
目的:研究去甲斑蝥素(NCTD)通过半胱氨酸天冬氨酸酶(caspase)途径诱导人宫颈癌HeLa细胞凋亡的机制.方法: 采用MTT法、形态学观察、......
【目的】寻找新的具有高杀虫活性的斑蝥素类化合物,为新型高效、低毒、低残留农药的研发提供参考。【方法】以去甲斑蝥素为先导化......
合成了11种γ-氨基丁酸异硫氰酯偶联去甲斑蝥素与取代苯胺目标化合物，其结构经IR、^1H NMR和HR—MS测试技术确证。抗惊厥活性初步测......
目的 研究去甲斑蝥素体内外对人骨肉瘤Saos-2细胞生长的抑制作用。方法 培养Saos-2细胞,24 h后随机分为空白对照组和去甲斑蝥素组(......
目的：观察去甲斑蝥素（NCTD）对高糖刺激的HK-2细胞外基质和TGF-β1表达的影响。方法：常规培养HK-2细胞，无血清DMEM培养基同步培养24h，细胞......
目的：通过体外观察去甲斑蝥素（NCTD）对LPS所致肝细胞损伤和TNF．仅表达的影响，探讨NCTD的作用及其机制。方法：胶原酶Ⅳ灌流分离培养大鼠肝......
目的：研究去甲斑蝥素对乳腺癌MCF-7细胞血管生成的影响并探讨其作用机制。方法：体外培养乳腺癌MCF-7细胞,分组干预,观察细胞的管腔样......
应用细胞培养、放射性核素示踪技术研究了去甲斑蝥素对白血病细胞的作用。结果表明，去甲斑蝥素对人早幼粒白血病ＨＬ－６０细胞株ＤＮＡ和蛋白质合成......
目的：制备去甲斑蝥素纳米粒（norcantharidin nanoparticles,NCTD-NP）,并考察其缓释特性和细胞毒性。方法：以聚乳酸-聚乙二醇为载体,采......
目的建立去甲斑蝥素原料药含量及有关物质的反相高效液相色谱测定方法。方法色谱柱为YWG-C18（4．6mm×250mm，5μm），流动相为甲醇-0．01......
目的探讨去甲斑蝥素联合传统方案治疗狼疮性肾炎的临床疗效。方法选取医院2016年1月至2018年1月收治的狼疮性肾炎患者100例,随机分......
目的:研究去甲斑蝥素(ND)对卵巢癌细胞增殖和侵袭能力的影响及分子机制。方法:CCK-8和Transwell检测不同浓度的ND给药后SKOV3细胞......
目的检测去甲斑蝥素对人鼻咽癌细胞CNE1增殖、凋亡的影响,为临床应用NCTD治疗鼻咽癌细胞提供实验基础。方法体外常规培养CNE1细胞......
