Lysosomes相关论文
Proteases comprise a variety of enzymes defined by their ability to catalytically hydrolyze the peptide bonds of other p......
Two-pore channels in intracellular Ca2+ mobilization induced by NAADP and functional coupling to oth
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The exploration of RNA methylation was rejuvenated in the second decade of this century with the discovery of FTO as m6A......
Pre-treatment with tumor cell-derived microparticles enhance the cytotoxicity of chemotherapeutic dr
Bladder cancer is the second most common genitourinary malignant disease in the USA, with an expected 69000 newly di......
目的探讨大鼠脑缺血再灌注后溶酶体组织蛋白酶L(Cathepsin L)与细胞凋亡的关系。方法选取10～12周龄的清洁级健康雄性Sprague-Dawley......
溶酶体内部呈酸性环境，含有50余种酸性水解酶以及多种溶酶体特异性膜蛋白，主要功能是接受和降解大分子物质。在某些肿瘤细胞中溶酶体......
Lysosomes are membrane-bound organelles for biomolecule degradation and recycling.They also serve as a nutrient sensing ......
Changes of balance between proteinase and their inhibitors in blood of pigs with high-velocity missi
Objective: To study the effect of imbalance between lysosomal enzymes and their inhibitors in blood on disturbance of th......
细胞膜屏障在保护细胞正常形态和功能的同时,也使很多有治疗作用的生物活性分子难以进入细胞内,使其应用受到极大限制.目前常用的......
Cells utilize calcium ions (Ca2+) to signal almost all aspects of cellular life,ranging from cell proliferation to cell ......
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
Changes of balance between proteinase and their inhibitors in blood of pigs with high-velocity missi
Objective: To study the effect of imbalance between lysosomal enzymes and their inhibitors in blood on disturbance of th......
The expression of synaptotagmin Ⅱ (Syt2) in RBL-2H3 (RBL) and its role during exocytosis of RBL was investigated. The e......
目的 研究WNK4激酶对BK通道的调节作用及机制.方法 将BK和WNK4野生型(WNK4-WT)或CD4(对照)质粒DNA共同转染进Cos-7细胞中,采用免疫......
应用陆栖无脊椎动物的生物标志物对土壤生态系统中污染物的暴露和效应进行评价日益受到重视,并取得了显著的研究进展.文中介绍了溶......
目的：证明黄芪多糖对氧化应激皮肤细胞的保护作用。方法：原代培养皮肤成纤维细胞在过氧化氢0．5mmol／L中，孵育30min造成急性氧化损伤的模......
目的：探讨大承气汤保护肠道屏障功能，治疗内毒素血症的理论，方法：体外实验选用大鼠肝溶酶体，体内实验选用内毒素所致家兔全身性施瓦茨曼......
Proteases comprise a variety of enzymes defined by their ability to catalytically hydrolyze the peptide bonds of other p......
Amyloid-beta peptide neurotoxicity in human neuronal cells is associated with modulation of insulin-
Extracellular deposits of the amyloid-beta peptide(Aβ) are known as the main pathological hallmark of Alzheimer's d......
大鼠腹腔注射百草枯（５０ｍｇ／ｋｇ）后２４ｈ，血浆和肺组织匀浆内丙二醛（ＭＤＡ）含量、血浆和支气管肺泡灌洗液（ＢＡＬＦ）酸性磷酸酶（ＡＣＰ）和β－葡萄糖醛酸苷酶（β－Ｇ）活性均显著升高，肺湿......
细胞死亡有凋亡（Ⅰ型）、自噬性细胞死亡（Ⅱ型）和坏死（Ⅲ型）三种方式。缺血性神经元的死亡影响着中风的发展进程。溶酶体是一种重要的细胞......
目的探讨局部麻醉药布比卡因对小鼠成肌细胞溶酶体的影响。方法将体外培养的小鼠成肌细胞C2C12分为2组。对照组：不加任何药物;布比......
自噬是一种复杂的代谢途径,通过溶酶体降解细胞内过剩的或多余的细胞质组分。另外,自噬是细胞自身调节维持稳态平衡的重要过程,也......
目的：研究奥美拉唑（omeprazole，ome）是否会增加小鼠胃癌的发病率并探讨其可能存在的机制。方法实验分为单纯对照组、ome 低剂量组（6 mg&......
Combination of kaempferol and chloroquine induces glioma cell death via expansion and subsequent rup
OBJECTIVE Chloroquine is considered as a potential chemotherapy and radiotherapy sensitizer,but the anticancer effect of......
背景：以往研究证实,CREG是一种与M6P/IGFⅡR直接结合的溶酶体蛋白,并依赖于与M6P受体的相互作用有效转运至溶酶体。目的：分析外源性C......
目的:研究溶酶体在蓖麻毒素A链(RTA)细胞内转运过程中的作用.方法:用DNA重组技术,将溶酶体的靶向信号肽KFERQ连接在RTA的羧基端;将......
自噬是一个细胞质成分被双层膜的囊泡包裹并与溶酶体融合降解的过程。肿瘤细胞利用自噬过程存活于代谢应激下,因此推测自噬抑制剂......
Feasibility study of cyclodextrins as active pharmaceutical ingredients for the treatment of GM1-gan
GM1-gangliosidosis is a rare lysosomal storage disorder characterized clinically by a wide range of variable neuroviscer......
Changes on lysosomal compartment during PMA-induced differentiation of THP-1 monocytic cells: Influe
In this work, the influence of different substrate adhesion during phorbol-12-myristate-13-acetate (PMA)-induced differe......
