EPIGENETIC相关论文
Central Asia––A Global Model for the Formation of Epigenetic Deposits in a Platform Sedimentary Cove
Metallogenic specialization of sedimentary cover in Central Asia is determined by its tec-tonic setting that governs the......
Diverse and precision therapies open new horizons for patients with advanced pancreatic ductal adeno
Pancreatic ductal adenocarcinoma (PDAC) is a common cause of cancer-related death, and most patients are with advanced d......
Design,synthesis and antitumor evaluations of nucleoside base hydroxamic acid derivatives as DNMT an
DNA methyltransferase (DNMT) and histone deacetylase (HDAC) are well recognized epigenetic targets for discovery of anti......
Assessing chromatin condensation for epigenetics with a DNA-targeting sensor by FRET and FLIM techni
Here we propose a fluorescent sensor,Chroma-V,consisted ofa Hoechst ligand (Hoe) to target chromatin DNA and a BODIPY ro......
Biodiversity-based development and evolution:the emerging research systems in model and non-model or
Evolutionary developmental biology,or Evo-Devo for short,has become an established field that,broadly speaking,seeks to ......
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Neural stem cells(NSCs)are capable of self-renewal and generate the major cell types in the brain....
Demethylation of Cxcr3 gene promoter and upregulation of CXCL10 after spinal nerve ligation contribu
DNA methylation has been implicated in the pathogenesis of chronic pain.Here we investigated how chemokine receptor CXCR......
Besides the conventional carbon sources,acetyl-CoA has recently been shown to begenerated from acetate in various types ......
Neural tube defects(NTDs)are severe,common birth defects that result from failure of neural tube closure,but their compl......
PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of gliob
Transcriptional deregulation plays a vital role in Glioblastoma multiforme(GBM).Thus,identification of epigenetic modifi......
neural tube defects,is a kind of serious congenital birth defects in the central Nervous system disease and is one of th......
By NMR techniques,we focused our studies on chemical biological mechanism in the epigenetics field.This talk will includ......
S-adenosylhomocysteine Accumulation Promotes Atherosclerosis by Epigenetic Regulation of Endoplasmic
Aim S-adenosylhomocysteine (SAH) is involved in the epigenetic mechanism of hyperhomocysteinemia pathogenicity of athero......
Treatment with epigenetic factors of 5-aza-deoxycytidine and TSA sensitize neurotoxic effects of neu
Parkinsons disease (PD) is a progressive neurodegenerative disease related to age,which primarily results from the death......
Histone deacetylation and acetylation status in memory T lymphocytes relates to allergen-induced eos
Background and objective:T lymphocyte,characterized by longevity and immune memory,play an important role for recurrent ......
Demethylation regulation of BDNF gene expression in dorsal root ganglion neurons is implicated in op
Repeated administration of morphine may result in opioid-induced hyperalgesia (OIH), which involves altered expression o......
Global DNA methylation was changed by a maternal high lipid and high energy diet during gestation an
前言 Epigenetic mechanism has been suggested to explain the effects of the maternal diet on the development of disease i......
Interphone Use Increases the Percentage of Lymphocytes through Modulating the Methylation of Wif-1 G
Background: Electromagnetic radiations (EMR) exposure has been identified as the causes of cardiovascular disease, adver......
Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promo
Purposes: To identify tumor suppressor genes (TSGs) silenced by aberrant promoter methylation and discover new epigeneti......
3,6-Dihydroxyflavone Suppresses Breast Carcinogenesis by Epigenetically Regulating miR-34a and miR-2
Our previous study selected a promising chemopreventive agent 3,6-dihydroxyflavone (3,6-DHF),and found 3,6-DHF significa......
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The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral
Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyc......
The Polycomb group (PcG) proteins are a family of chromatin regulators and critical for the maintenance of cellular iden......
Primary malignant brain tumors are a major cause of morbidity and mortality in both adults and children,with a dismal pr......
RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING:HORMONE,TRANSCRIPTION FACTOR AND EPI
Fruit ripening is a complex developmental process made up of genetically programmed physiological and biochemical activi......
Epigenetic modification regulates developmental lead exposure induced Attention DeficitHyperactivity
Lead(Pb)exposure was commonly considered as a high environmental risk factor for the development of attention-defici......
The haploid multicellular male gametophyte of plants, the pollen grain, is a terminally differentiated structure who......
Genetic and Epigenetic Signals Are Found Predictive to the Distribution of Intra-individual Divergen
Alternative splicing is a major mechanism for creating multiple mRNAs from a single gene and plays critical role in ......
Background: Nucleosome positioning plays an important role in regulation of the gene activity in eukaryotic cell.DNA......
Global DNA methylation was changed by a maternal high lipid and high energy diet during gestation an
Epigenetic mechanism has been suggested to explain the effects of the maternal diet on the development of disease in......
The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral
Objective: To assess the efficacy and safety of the novel histone deacetylase inhibitor, chidamide, in combination with ......
Both eukaryotic and prokaryotic pathogens infect the host stably via an immune evasion mechanism termed mutually exclusi......
Cryopreservation of spermatozoa is a strategy that has been used to conserve the sperm of animal species and animal stra......
MicroRNA (miRNA) alterations in response to changes in an extracellular microenvironment have been observed and consider......
Research led by scientists from University College London(UCL),Queen Mary University of London(QMUL)and Dr.Andrew E.Tesc......
Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epi
In our previous studies, significant hypermethylation of the sirtuin 1(SIRT1) gene and demethylation of the b-amyloid pr......
Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. ......
Diabetes has become the epidemic of the 21 st century, and with over 90% patients with diabetes becoming at a risk of de......
Epigenetic modifications include DNA methylation, his-tone modifications, and micro RNA. Gene alterations have been foun......
Expression of Dnmt1,demethylase,MeCP2 and methylation of tumor-related genes in human gastric cancer
AIM:To explore the effect of DNA methyltransferase,clemethylase and methyI-CpG binding protein MeCP2 onthe expressions ......
Enrichment of arsenic, antimony, thallium and selenium in high-arsenic coal from Xingren County, Gui
Since 1976 high arsenic coal in Xingren County, Guizhou Province, has attracted more and more attention because of coal-......
Generality and characteristics of genetic and epigenetic changes in newly synthesized allotetraploid
Previous studies have shown rapid and extensive genomic instability associated with early stages of allopolyploidization......
流行病学研究显示,在砷暴露人群中肺癌、膀胱癌和肝癌等发生比例较高.作为弱致突变致癌物,砷诱导肿瘤的发生机制尚未完全阐明.近年......
目的 研究子宫内膜癌(EC)中相关抑癌基因(SOCS-1、SOCS-3、3-OST-2、DLC-1)的启动子甲基化状态,探讨其临床病理意义.方法 收集60例......
在人、小鼠和中国地鼠细胞系及这些细胞融合后所获得的杂交细胞中,作者研究了病毒和PolyI:C诱导的干扰素合成,目的是观察诱导剂和......
Denervation often results in skeletal muscle atrophy.Different mechanisms seem to be involved in the determination betwe......
Parkinsons disease(PD) is a common,progressive neurodegenerative disease characterised by degeneration of nigrostriatal ......
