ENANTIOMER相关论文
A growing number of chiral compounds were produced and served in pharmaceutical and insecticidal industry,which arouses ......
Citalopram,chemically 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroiso-benzofuran-5-carbonitrile,is a seroton......
Pharmacokinetics and brain distribution kinetics of thiencynonate enantiomers in rats using microdia
Objective To investigate the pharmacokinetics and brain distribution kinetics of the two enantiomers of the novel antich......
The separation of optical isomers is an important subject in the pharmaceutical field.Much of the groundbreaking work in......
Iniferter-mediated grafting of molecularly imprinted polymers on porous silica beads for the enantio
A surface-imprinted chiral stationary phase for the enantiomeric resolution of the antidepressant drug citalopram is......
Three chiral compounds were successfully separated in a short time with two enantiomer separation models on packed-capil......
THERMODYNAMIC ANALYSIS OF THE ENANTIOMER RESOLUTION OF TFA-Ala-OMe, TFA-Ala-Ala-OMe, AND TFA-Ala-Ala
TFA-Ala-OMe, TFA-Ala-Ala-OMe, and TFA-Ala-Ala-Ala-OMe can be separated into 1, 2, and 4 enantiomeric pairs, respectively......
目的：建立拆分萘普生对映体的方法。方法：采用超临界流体色谱法。以萘普生对映体的分离时间、容量因子、分离因子、分离度为考察指标......
目的:建立了HPLC法直接检测卡非佐米光学异构体的方法。方法:采用Chiralpak OX-H手性柱,以正己烷-异丙醇-乙醇(89∶5∶6,v/v/v)为......
目的:建立测定甲磺酸沙芬酰胺中对映异构体含量的方法。方法:采用HPLC法,色谱柱:Chiralpak AS-H柱(250mm×4.6 mm,5μm);流动相:正......
目的建立多奈哌齐、吡格列酮、罗格列酮、坦洛新、佐米普曲坦、普奈洛尔、丙卡特罗和替加氟8种药物对映体手性分离方法,并考察几种......
目的 建立测定盐酸替罗非班光学异构体的高效液相色谱方法.方法 采用ULTRON ES-OVM(4.6 mm×150 mm,5μm)手性柱,以8％(m/m)醋酸铵缓......
建立并优化了高效液相色谱手性固定相分离盐酸克伦特罗对映体的方法。使用两种Pirkle型手性固定相(α-Burke-2和Pirkle-1J)拆分了......
使用高效液相色谱-柱前衍生化法测定了(s)-2-氨基丁酰胺盐酸盐的对映异构体.采用梯度洗脱;流动相A为0.1 moVL乙酸铵溶液,流动相B为......
Development of a UHPLC-MS/MS method for the quantification of ilaprazole enantiomers in rat plasma a
In Korea and China, ilaprazole is a widely used proton pump inhibitor in the treatment of gastric ulcers. In this study,......
本文建立了一种简单有效的高效液相-紫外检测法测定分离恩替卡韦光学异构体.恩替卡韦化学结构中有3个手性原子,恩替卡韦有7个光学......
Two Novel Homochiral Enantiomorphic 3D Metal-organic Frameworks: Synthesis, Crystal Structure, Lumin
本文通过对荣华二采区10...
Ibuprofen is widely used as a non-steroidal anti-inflammatory drug and produced as racemic mixture. Its pharmacological ......
Analysis of chiral non-steroidal anti-inflammatory drugs flurbiprofen, ketoprofen and etodolac bindi
The protein binding of non-steroidal anti-inflammatory drugs flurbiprofen, ketoprofen and etodolac with human serum albu......
建立了高效液相色谱法同时测定盐酸达卡他韦及其5个光学异构体。采用Chiralpak IC色谱柱,以甲基叔丁醚(含0.1%二乙胺)∶甲醇(88∶1......
本文通过对荣华二采区10...
目的采用手性固定相高效液相色谱法拆分异丙肾上腺素对映体。方法以氯甲酸苄酯作为非手性衍生化试剂,与异丙肾上腺素进行衍生化反......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的 研究不同甲氨蝶呤(MTX)对映体耐药与叶酰聚谷氨酸合成酶(FPGS)基因水平表达的关系.方法 用大剂量冲击递增结合低剂量持续诱导......
Distribution behavior of ketoprofen enantiomers was examined in methanol aqueous and organic solvent mixture containing ......
目的:建立酮洛芬对映异构体的拆分方法。方法:采用柱前衍生化RP-HPLC法,以L-丙氨酸-β-萘胺(L-Ala-β-NA)为手性衍生化试剂,色谱柱......
Two new chiral stationary phases, 2,3-di-O-acetyl-6-O-trimethylsilyl-β-cyclodextrin (DATBCD)and 2, 6-di-O-trimethylsily......
建立直接拆分氨氯地平对映体的HPLC方法,并用于其含量测定.以CHIRALPAK AD-H为固定相,在正相条件下考察了流动相组成、流速、柱温......
建立了液相色谱-串联质谱(LC-MS/MS)法测定犬血浆中的泮托拉唑(1)对映异构体,并应用于1在Beagle犬体内立体选择性药动学研究。采用......
Analysis of chiral non-steroidal anti-inflammatory drugs flurbiprofen, ketoprofen and etodolac bindi
The protein binding of non-steroidal anti-inflammatory drugs flurbiprofen,ketoprofen and etodolac with human serum album......
Erythromycin as a new chiral selector was first used for chrial separation of four derivatives of biphenyldimethylester ......
Starting from shikimic acid, the total synthesis of zeylenone was studied. The product was proved to be the (+)antipode ......
Many of the drugs currently used in medical practice are racernates.The enantiomers of a racemic drug differ in pharrnac......
Development of a UHPLC-MS/MS method for the quantification of ilaprazole enantiomers in rat plasma a
In Korea and China,ilaprazole is a widely used proton pump inhibitor in the treatment of gastric ulcers.In this study,a ......
在辅助配体3-(2-甲基-1H-咪唑-1-基)-5-(5-甲基-1H-咪唑-1-基)吡啶(MIMIP)的辅助下,乳酸衍生物(R)-4-(1-羧基乙氧基)苯甲酸((R)-H_......
粉唑醇是三唑类杀菌剂，化学名称为α-(2-氟苯基)-α-(4-氟苯基)-1H-1,2,4-三唑-1-乙醇(其化学结构见Scheme 1),存在1对对映异构体.......
目的研究布洛芬离体肝代谢中对映体之间的相互作用.方法用家兔肝匀浆质与单纯的R(-)-或S(+)-布洛芬以及两对映体以不同比例的混合......
以DL-1-苯乙醇为唯一碳源从土壤微生物中筛选出1株高度立体选择性还原苯乙酮为S-1-苯乙醇的产酶菌株No.XC35-8。对发酵条件进行了......
通过测定日本Ｄａｉｃｅｌ公司出售的Ｃｈｉｒａｌｃｅｌ－ＯＪ柱的Ｖａｎ－Ｄｅｅｍｔｅｒ曲线可知Ｃｈｉｒａｌｃｅｌ－ＯＪ柱的Ｖａｎ－Ｄｅｅｍｔｅｒ曲线与一般的手性柱的Ｖａｎ－Ｄｅｅｍｔｅｒ曲线不同，曲线不仅出现了最低点而且出了最高点。实验结果表明，随着流......
研究了８名中国健康男性受试者单剂量口服奥美拉唑（ＯＰＺ）胶囊２０ｍｇ后（－）－ＯＰＺ和（＋）－ＯＰＺ在体内药代动力学的立体选择性规律。用手性固定相ＨＰＬＣ法，测定了服药后０．５，１．０，１．５，２．０，３．０，４．０，６．０ｈ不同时刻......
Ｅｎａｎｔｉｏｍｅｒｉｃａｌｙｐｕｒｅ１，１＇－ｂｉ－２－ｎａｐｈｔｈｏｌｓ（１Ａ，１ＢＳｃｈｅｍｅⅠ）ｈａｖｅｐｒｏｖｅｄｔｏｂｅｖｅｒｙｕｓｅｆｕｌｃｈｉｒａｌａｕｘｉｌｉａｒｉｅｓｉｎｓｔｏｉｃｈｉｏｍｅｔｒｉｃａｎｄｃａｔａｌｙｔｉｃａｓｙｍ.........
A Convenient Preparation of Enantiopure 1,1’-bi-2-naphthols via an Inclusion Complexation in the Sol
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目的研究尼卡地平(NCD)对映体在家兔体内药代动力学和组织分布的差异性。方法生物样品在碱性条件下，正己烷-醋酸乙酯(1∶1)提取，用手......
目的:研究那格列奈在健康受试者体内的药代动力学特征及生物转化过程中的消旋化.方法:8名健康受试者单剂量口服那格列奈90mg,用RP-......
氨基酸能参与多种多样的生命活动，此外它还是合成多种药物的重要中间体。大多数氨基酸都有一个或一个以上的手性中心，手性不同其生物......
采用气相色谱法，使用OV-171m×3mm（id）色谱柱，在柱温190℃时测定精吡氟禾草灵含量；同时采用液相色谱法，使用NUCHI手性色谱柱，以甲醇为......
