CHOLESTASIS相关论文
Impaired Compensatory Vasodilatory Effect Mediated by Wolfram Syndrome 1 and Corticotropin-Releasing
Objective::To investigate the possible regulatory mechanism of corticotropin-releasing hormone (CRH), urocortin (UCN), a......
Dysregulated Hepatic Expression of Glucose Transporter Type-1, Toll-Like Receptor 4, and Nuclear Fac
Objective::This study aimed at investigating the expression of nuclear factor kappa B (NF-κB) and mammalian target of r......
Unilateral versus bilateral Y-type stent-in-stent metal stent insertions in inoperable malignant hil
Background: To date, there is controversy regarding unilateral versus bilateral stent placement in patients with maligna......
Targeted bile acids and gut microbiome profiles reveal the hepato-protective effect of WZ tablet (Sc
Cholestasis is caused by the obstacle of bile formation or secretion and can develop into severe liver diseases.We previ......
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Alagille syndrome (ALGS) is an autosomal dominant disorder characterized by genetic abnormalities of Jag1 and the Notch ......
Complement factor C3 deficiency significantly attenuates the cholestatic liver injury in bile duct-l
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The Application of Laparoscopy in Diagnose andTreatment of Infant Cytomegalovirus Hepatitis(Cholesta
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Inhibition of Notch signaling pathway prevented cholestatic liver fibrosis through decrease the diff
Although hepatic progenitor cells(HPCs)are known to contribute to cholestatic liver fibrosis(CLF),how Notch signaling mo......
A serum metabolomic investigation of cholestasis on an experimental model of bile duct ligation in r
Metabolomics follows the changes in concentrations of endogenous metabolites,which may reflect various disease states as......
Tolvaptan induces cholestasis and hepatoxicity through altered expression and function of transporte
Tolvaptan is an orally active vasopressin V2 receptor antagonist clinically used in the treatment of hyponatremia.Recent......
Objective: To examine whether hypothyroidism is an extrahepatic feature of ATP8B1 deficiency.Study design: 47 children w......
Biliary atresia (BA) is an important cause of neonatal obstructive surgical jaundice.Laparoscopic cholangiography is usu......
Sweroside ameliorates α-naphthylisothiocyanate induced cholestatic liver injury through bile acid re
Aim: Sweroside, an iridoid glycoside, exerts diverse biological activities.The study aimed to investigate how sweroside ......
Role of ERα and nuclear receptor on 17α-ethInylestradiol-induced intrahepatic cholestasis in pregnan
Intrahepatic cholestasis of pregnancy (ICP) has been associated with premature delivery and an increased risk for intrau......
Objective: This study aims to evaluate the efficacy and safety of the Yinchenhao decoction in treating cholestasis.Metho......
BACKGROUND AND PURPOSE: Tumor suppressor p53 is traditionally recognized as a surveillance molecule to preserve genome i......
Atorvastatin alters the expression of genes related to inflammation, bile acid metabolism and circad
Statins are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors clinically used for hyperlipidemia.Statins are ge......
EB病毒（EBV）感染与青少年和成人肝损伤密切相关，临床特征多样。常表现为传染性单核细胞增多症时的急性自限性肝炎，特点是以转氨酶轻、......
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OECTIVE Baicalin is a major flavonoid component of Scutellaria baicalensis,and has been used in the treatment of liver d......
Progressive familial intrahepatic cholestasis—farnesoid X receptor deficiency due to NR1H4 mutation:
BACKGROUND Functioning farnesoid X receptor(FXR;encoded by NR1H4)is key to normal bile acid homeostasis.Biallelic mutati......
Liver injury associated with the use of selective androgen receptor modulators and post-cycle therap
BACKGROUND Muscle growth promoters are being developed for the treatment of diseaseinduced loss of muscle mass.Ligandrol......
Application of Biochemical Tests and Machine Learning Techniques to Diagnose and Evaluate Liver Dise
<b><span style=\"font-family:Verdana;\">Background: </span></b><span style=\"font-family:\"\"><span style=\"......
Genotyping is definitive for the diagnosis of mitochondrial DNA depletion syndrome (MDS).Here we report a Chinese in......
A Retrospective,Multi-Center,Post-Marketing Observational Study to Evaluate the Effectiveness of Ade
Ademetionine 1,4-butanedisulfonate[S-adenosyl-L-methionine(SAMe)/Transmetil~,Abbott]has been available in China for mo......
<正>胆汁淤积(cholestasis)因胆汁摄取、合成或分泌障碍引起,也可因胆道梗阻形成[1]。引起胆汁淤积的病因多样,肝细胞、胆管细胞以......
Placental expressions of estrogen receptor α,estrogen receptor β in intrahepatic cholestasis of preg
Objective:To investigate the association of the expression of estrogen receptor α,estrogen receptor β in placenta with......
Genotyping is conclusive for the diagnosis of progressive familial intrahepatic cholestasis type 3(PFIC3). Here we repor......
Matrix metalloproteinases(MMPs) are a family ofproteases using zinc-dependent catalysis to break down extracellular matr......
Glucosamine(GS) and chondroitin sulfate(CS) are common over-the-counter(OTC) supplements used in the treatment of osteoa......
妊娠期黄疸在临床上较常见,其中最常见是妊娠期肝内胆汁淤积症(intrahepatic cholestasis ofpregnancy,ICP)和妊娠期病毒性肝炎(v......
Paediatric cholestatic liver disease:Diagnosis,assessment of disease progression and mechanisms of f
Cholestatic liver disease causes significant morbidity and mortality in children.The diagnosis and management of these d......
Biliary atresia(BA) is one of the major hepatobiliary abnormalities in infants and one of the causes of hepatic osteodys......
Clinical Study on Treatment of Infantile Cytomegalovirus Hepatitis with Integrated Chinese and Weste
Objective:To evaluate the efficacy and safety of Chinese medicine(CM) in treating infantile cytomegalovirus hepatitis(IC......
AIM:To explore differences in biochemical indices between neonatal intrahepatic cholestasis caused by citrin deficiency ......
Different regional distribution of SLC25A13 mutations in Chinese patients with neonatal intrahepatic
AIM: To investigate the differences in the mutation spectra of the SLC25A13 gene mutations from specific regions of Chin......
BACKGROUND:Biliary atresia(BA) is a major cause of chronic cholestasis,a fatal disorder in infants.This study was undert......
近年来,随着新生儿危急重症诊疗技术的不断提高,许多极低、超低体重儿、危重新生儿得以存活,其中胃肠外营养(parenteral nutrition......
AIM:To determine the frequencies of diagnoses confirmed by liver biopsy in infants with cholestasis in an Iranian pediat......
Two novel VPS33B mutations in a patient with arthrogryposis,renal dysfunction and cholestasis syndro
Arthrogryposis,renal dysfunction and cholestasis(ARC)syndrome is a rare genetic disorder and has not been described in C......
Several conditions, especially chronic liver diseases, can lead to cirrhosis in children and adolescents. Most cases in ......
Citrin deficiency typically presents as neonatal intrahepatic cholestasis and resolves in late infancy.Here we report a ......
Hepatic phenotypes of HNF1B gene mutations:A case of neonatal cholestasis requiring portoenterostomy
Hepatocyte nuclear factor 1-β(HNF1B)defects cause renal cysts and diabetes syndrome(RCAD),or HNF1B-maturity-onset diabe......
Liver transplantation and the management of progressive familial intrahepatic cholestasis in childre
Progressive familial intrahepatic cholestasis(PFIC) is a constellation of inherited disorders that result in the impairm......
Decidual lymphocytes may mediate fetal trophoblast recognition and regulate maternal immune reaction and play an essenti......
