Amyloid-β相关论文
Blood exosomes, which are extracellular vesicles secreted by living cells into the circulating blood, are regarded as a ......
Anodal transcranial direct current stimulationalleviates cognitive impairment in an APP/PS1 model of
Anodal transcranial direct current stimulation (AtDCS) has been shown to alleviate cognitive impairment in an APP/PS1 mo......
Lycium barbarum extract promotes M2 polarization and reduces oligomeric amyloid-β-induced inflammato
Lycium barbarum (LB) is a traditional Chinese medicine that has been demonstrated to exhibit a wide variety of biologica......
Hydrogen exhibits the potential to treat Alzheimer\'s disease. Stereotactic injection has been previously used as an i......
Positron emission tomography imaging for the assessment of mild traumatic brain injury and chronic t
A chronic phase following repetitive mild traumatic brain injury can present as chronic traumatic encephalopathy in some......
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Our previous studies proposed that Alzheimer\'s disease (AD) is a metabolic disorder and hypothesized that abnormal br......
Novel Zn-BTMPAMP complex for Cu-exchange in amyloid-β-Cu protects against copper-induced amyloid-β t
Abnormal interactions of copper and zinc ions with amyloid-β(Aβ)peptide play a critical role in the pathogenesis of Al......
The Variation of Hydroxyl Groups on the Flavonoid Backbone Directs the Modulation of Cu(Ⅱ)-Aβ Aggreg
Amyloid-β(Aβ)and transition metal ions have been suggested to be involved in the pathogenesis of Alzheimers disease(AD......
Objective Alzheimers disease (AD) is one of the most common forms of neurodegenerative disease.Amyloid-β (Aβ) is consi......
Accumulation of brain amyloid-β is a pathological feature of Alzheimers disease.Dyshomeostasis of bivalent metals such ......
Objective: Ceruloplasmin(CP),with ferrous oxidase activity,plays an important role in regulating iron metabolism and red......
Objective We previously found that sustained expression of interleukin(IL)-1b in mouse brain led to reduction in plaque ......
Oxidative stress and inflammation as the pathoogical components of Alzheimer s disease (AD) have been well understood.Am......
Electroacupuncture improves cognitive impairment and brain damage in senescence-accelerated mouse pr
OBJECTIVE: The senescence-accelerated mouse prone 8 (SAMP8) is an autogenic senile model characterized by early cognitiv......
Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice:involvement of amyi
Aim: To examine the effects of pioglitazone, a PPART agonist, on memory performance and brain amyloidogenesis in strepto......
Senile plaques(SPs)are one of the pathological features of Alzheimer\'s disease(AD)and they are formed by the overprod......
Cu 和Zn 等离子参与了大脑中β-淀粉样多肽(amyloid-β peptide,Aβ)的聚集过程和活性氧(reactive oxygen species,ROS)的产生......
Alzheimers disease(AD)is widely recognized as a serious public health problem,of which Amyloid-β(Aβ)-induced oxida......
Neuropeptide S Enhances Memory and Mitigates Memory Impairment Induced by MK801, Scopolamine or Aβ1-
A growing body of evidence suggests that the endogenous ligand of NPSR,NPS,could promote arousal and anxiolytic-like......
Interleukin-4 plays an important protective role in Alzheimer’s disease by regulating microglial phenotype, phagocytosi......
Tiaoxin Recipe, a Chinese herbal formula, inhibits microRNA-34a expression in the APPswe/PS1△E9 mous
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Amyloid cross-seeding between Aβ and hIAPP in relation to the pathogenesis of Alzheimer and type 2 d
Amyloid cross-seeding of different amyloid proteins is considered as a highly possible mechanism for exacerbating the tr......
Cyanidin attenuates Aβ25-35-induced neuroinflammation by suppressing NF-κB activity downstream of TL
Cyanidin is polyphenolic pigment found in plants. We have previously demonstrated that cyanidin protects nerve cells aga......
Alzheimer’s disease (AD) is the most common type of dementia that affects thinking,leing,memory and behavior of older p......
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目的探讨叶酸缺乏对APP/PS1双转基因阿尔茨海默病（Alzheimer’s disease, AD）模型小鼠脑组织中早老素1(Presenilin1)基因表达和β-淀......
To enhance anti-amyloid-beta(Aβ) antibody generation and induce a Th2 immune response,we constructed a new DNA vaccine ......
Senile plaques(SPs)are one of the pathological features of Alzheimer’s disease(AD)and they are formed by the overproduc......
目的：研究姜黄素（Cur）对β-淀粉样蛋白（Aβ）刺激下大鼠原代小胶质细胞活力及高迁移率族蛋白1（HMGB1）、白细胞介素-1β（IL-1β）、肿瘤坏死因......
目的探讨术后认知功能障碍（POCD）与外周血α1-抗糜蛋白酶（ACT）的关系。方法选择于全身麻醉下行手术的患者60例,分别于术前1d和术后7d采......
目的:制备靶向β-淀粉样蛋白(Aβ)的单链抗体(scFv),探究其体外活性。方法:原核表达系统对scFv进行表达。ELISA、免疫组化法检测sc......
目的探讨贯叶金丝桃素衍生物GF1029对大鼠原代培养皮层细胞的保护作用及对衰老模型小鼠空间探索能力和脑抗氧化酶的影响。方法采用......
Inhibition of BACE1, the β-secretase implicated in Alzheimer’s disease, by a chondroitin sulfate ext
The pharmaceutical and anticoagulant agent heparin,a member of the glycosaminoglycan family of carbohydrates,has previou......
目的观察β-淀粉样蛋白（Aβ）_（25-35）对大鼠海马Caspase-3及P38MAPK mRNA表达的影响。方法雄性Sprague-Dawley（SD）大鼠24只,随机分为正常......
用常规的T2加权像研究阿尔茨海默病双转基因APPswe/PS1dE9小鼠模型,拟合了海马和顶叶皮层的T2,并用组织学方法研究了APP/PS1小鼠在......
β-淀粉样多肽（β-amyloid peptide,Aβ）在细胞膜上的错误折叠和聚集与阿尔茨海默病的发病机理有关,研究Aβ和细胞膜之间的相互作用......
综述了锌和铜在阿尔茨海默病中的作用及阿尔茨海默病患者脑中氧化还原活性金属之间的相互作用与作用机理,提出阿尔茨海默病的螯合......
The Alzheimer’s disease (AD) is the most widespread chronic, insidious neurodegenerative disease causing dementia in el......
Adipocyte-derived leptin is a pleiotropic hormone implicated in control of lipid storage and mobilization, bone homeosta......
Interleukin-4 plays an important protective role in Alzheimer’s disease by regulating microglial phenotype,phagocytosis......
Action of trichostatin A on Alzheimer’s disease-like pathological changes in SH-SY5Y neuroblastoma c
The histone deacetylase inhibitor, trichostatin A, is used to treat Alzheimer’s disease and can improve learning and me......
Although amyloid-β peptide is considered neurotoxic, it may mediate several physiological processes during embryonic de......
Objective:Alzheimer’s disease( AD) is the most common neurodegenerative disorder which is characterized by amyloid-β( ......
Alzheimer’s disease (AD) is the most common form of dementia which mostly affects persons younger than 65 years old. Mo......
目的：探讨Aβ25-35介导SH-SY5Y细胞Bcl-2、Bax基因表达改变是否通过基因启动子区甲基化的机制。方法不同浓度Aβ25-35（0、25、50μmo......
