ANTICONVULSANT相关论文
Synthesis and potential anticonvulsant activity of N-3-amino substituted 5,5-cyclopropanespirohydant
Epilepsy is a common neurologic affection characterized by excessive temporary neuronal discharge that affects about 1%o......
IE-PP30:Pharmacophore screening with piperdinecarboxamides derivatives using GALAHAD study and CoMFA
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目的设计合成新型缩氨基脲类化合物,探讨结构中同时含有海因和缩氨基脲片段时其抗癫痫和抗肿瘤活性。方法依据拼合原理,将具有抗癫......
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,Design, molecular docking, synthesis, characterization, biological activity evaluation (against MES
BACKGROUND:Among the reported potential agents to treat the epilepsy,sulphonamides are important and their significance ......
Objective: To investigate the antipyretic and anticonvulsant activities of n-hexane fraction of Viola betonicifolia (V. ......
Progress in studies on the role of gamma-aminobutyric acid type A receptor in convulsion: a short re
Convulsion is the medical condition where body muscles contract and relax rapidly and repeatedly,resulting in an uncontr......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Synthesis and evaluation of 4-substituted semicarbazones of levulinic acid for anticonvulsant activi
Objective: A series of 4-aryl substituted semicarbazones of levulinic acid (4-oxo pentanoic acid) was designed and synth......
Synthesis and anticonvulsant activity of 1-substituted benzyl-N-substituted-1, 2, 3-triazole-4-for-m
Substituted benzyl azids were synthesized through the reaction of substituted benzyl chloride and sodium azid, which sub......
Progress in studies on the role of gamma-aminobutyric acid type A receptor in convulsion: a short re
Convulsion is the medical condition where body muscles contract and relax rapidly and repeatedly,resulting in an uncontr......
Synthesis and anticonvulsant activity of 7-benzylamino-4, 5-dihydro- [ 1, 2, 4] triazolo[ 4, 3-a] qu
A series of 7-substituted-benzylamino-4, 5-dihydro-[ 1,2, 4]triazolo[4, 3-a] quinoline derivatives was synthesized and e......
以对氨基酚为起始原料合成了一系列2-(4-(1,2,4-三唑)-苯氧基乙酰腙衍生物(5a-5o)。通过核磁共振氢谱和碳谱确证了目标化合物的结......
目的合成一系列3-芳基-1H-5-取代吡唑酰腙类化合物,用于抗癫痫和抗炎活性筛选.方法以苯乙酮(或取代苯乙酮)为起始原料与草酸二乙酯......
目的：介绍一种同时进行４路流体灌流的多孔脑片浴槽。方法：用大鼠朋脑皮层脑片细胞外电极记录，观察自发性癫痫样放电。结果：通过染料试验......
合成了11种γ-氨基丁酸异硫氰酯偶联去甲斑蝥素与取代苯胺目标化合物，其结构经IR、^1H NMR和HR—MS测试技术确证。抗惊厥活性初步测......
用Fibonaeci寻找法及Topliss方法设计并合成了14个1-取代-5-苯基-3-吡唑烷酮化合物。药理实聆表明,11个化合物具有抗惊厥活性,其中......
癫痫是一种由多种原因引起的脑部神经元群阵发性异常放电所致的植物神经功能异常的疾病，以反复发作性、短暂性、通常为刻板性的中枢......
天然产物加锡果宁(edulinine)具有镇痛,麻醉、抗惊厥等中枢神经抑制活性。作者在其结构基础上,采用了Topliss和Austel等的定量药物......
3，5-二氯-2-戊酮经硫氰化、闭环反应得到4-甲基-5-（2-氯乙基）-2-羟基噻唑，和磷酰氯反应后用钯炭催化氢解脱氯，制得盐酸氯美噻唑，总收率61......
Synthesis and evaluation of 4-substituted semicarbazones of levulinic acid for anticonvulsant activi
Objective: A series of 4-aryl substituted semicarbazones of levulinic acid (4-oxo pentanoic acid) was designed and synth......
目的:探讨抗惊厥药所致药物超敏综合征(DHS)的临床特征.方法:回顾分析19例抗惊厥药所致DHS患者的临床表现、实验室检查、治疗方法......
以戊四氮诱发小鼠惊厥为模型，观察单用牛磺酸及联合用苯巴比妥钠的抗惊厥作用，并测定牛磺酸对脑中ｒ－氨基丁酸（ＧＡＢＡ）、牛磺酸、谷氨酸水平的影......
目的：探讨用手术切除的癫痫病灶进行抗癫痫药物研究的可行性。方法：将手术中切除大脑皮层病灶切成脑薄片，通过脑标本的降温通氧保存脑......
目的 探讨抗癫痫药物（AED）卡马西平（CBZ）和丙戊酸钠（VPA）血清中浓度与唾液中浓度的相关性及其CBZ、VPA在唾液中的稳定性，明确唾液监测AED......
根据药物设计原理,设计合成了一系列二甲吡唑联苯并噻唑衍生物并且研究其抗惊厥活性。实验结果表明:在所有衍生物中,当取代基为烷......
狼毒大戟碱性提取液(EBLE)两种剂量分别腹腔注射给药,可明显对抗小鼠最大电休克惊厥,抗惊率分别为53％和63％。EBLE 亦能提高戊四唑、......
We report here the synthesis and in vivo anticonvulsant/neurotoxicity activities of a series of compounds belonging to 2......
Synthesis and Evaluation of Anticonvulsant Activity of 6,8-Dimethoxy-3-methyl-1,2,3,4-tetrahydroisoq
This study we describe the synthesis of a novel structure of anticonvulsant agent as 6,8-dimethoxy-3-methyl-1,2,3,4- tet......
Synthesis and Evaluation of Anticonvulsant Activity of 6,8-Dimethoxy-3-methyl-1,2,3,4-tetrahydroisoq
This study we describe the synthesis of a novel structure of anticonvulsant agent as 6,8-dimethoxy-3-methyl-1,2,3,4- tet......
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Trigeminal neuralgia(TN)is characterized by recurrent facial acupuncture like,electric shock like,burning like pain and ......
Studies on the Relationship Between the Structure and Anticonvulsant Activity of Cinnamamides and Th
On the basis of systematic modification of the structure of componds of antiepilepsirine type, more than 200 cinnamamide......
Objective:To investigate the antipyretic and anticonvulsant activities of n-hexane fraction of Viola betonicifolia(V.bet......
Epilepsy is described as the most common chronic brain disorder. A typical symptom of epilepsy results in uncontrolled c......
奥卡西平（oxcarbazepine，1），化学名为10，11-二氢-10-氧代-5H-二苯[b，f]氮杂[艹卓]-5-甲酰胺，由瑞士Novartis公司研发，1990年首次在丹麦上市......
