BACKGROUND:Among the reported potential agents to treat the epilepsy,sulphonamides are important and their significance cannot be ignored.A series of substituted 4-amino-benzene sulfonamides were designed,keeping in view the structural requirement of pharmacophore.METHODS:Lipinski rule of five has been calculated;failure to Lipinski rule was not observed.Docking was performed through AutoDock Vina.Molecules have been screened out through docking.Compounds were synthesized and characterized through IR,1HNMR,13C NMR,Mass and elemental analysis.The anticonvulsant activity of the synthesized compounds was assessed using the Maximal Electroshock Seizure (MES) model.In-silico biological activity spectrum,toxicological studies,predicted oral rats LD50 were performed.RESULTS:Docking studies showed good interaction with lyase (Oxo-acid)-human carbonic anhydrase-I (1AZM).The in-silico studies proved them to be with good drug-likeness properties,especially 4-(3-Acetyl-phenylamino)-methyl)-benzenesulfonamide (2g).These results revealed that the synthesized compounds (1a-1c,2a-2q) exhibited promising anticonvulsant effect against MES model for inhibition of Lyase-Human Carbonic Anhydrase-I.CONCLUSION:After investigating all the results,the compound 4-(3-Acetyl-phenylamino)-methyl)-benzenesulfonamide (2g) is found to be best in the series.A comparatively good activity of compound 2g suggests us that sulphonamide can be leads to further optimization for building potent and chemically diversified anti-convulsant agents.