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1.前言本文报道的是近年药物研究的新进展。前报所报道的新神经肽,还处在深入的基础研究阶段,尚未作药物使用。 2.麻醉药和镇痛药 2.1 强效镇痛药 Dynorphin(1)是1979年从猪垂体分离到的13肽。这是最强的天然存在的神经多肽之一,通过1的研究使阿片受体得到了认识与证实。 H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile- Arg-Pro-Lys-Leu-Lys-OH 1 H-Try-D-Ala-Phe-Gly-Try-Pro-Ser-NH_2 2 1 对豚鼠大肠的作用较去甲吗啡几乎强
1. Introduction This article reports new developments in drug research in recent years. The new neuropeptides reported in the previous report are still in the deep basic research phase and have not been used for drugs. 2. Narcotic drugs and analgesics 2.1 Potent analgesics Dynorphin (1) was isolated from pig pituitary 13 peptide in 1979. This is one of the strongest naturally occurring neuropeptides, and opioid receptors have been recognized and confirmed through the study of 1. H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH 1 H-Try-D-Ala-Phe-Gly-Try-Pro-Ser-NH 2 2 1 on guinea pig large intestine is almost stronger than normorphine