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糖尿病晚期并发症主要分为小血管病(如肾病、视网膜病)和大血管病(如心血管障碍),是糖尿病患者高度致残和致死的主要原因。研究表明,这些并发症的发生与遗传因素有关。而编码肾素-血管紧张素系统蛋白产物的基因,是与糖尿病血管病并发症有关的候选基因。血管紧张素Ⅰ转换酶(ACE)是肾素-血管紧张素系统的重要成分,可将血管紧张素Ⅰ转换成具有血管收缩、促进血管和心肌平滑肌细胞增殖,并经肾上腺皮质醛固酮加强肾钠重吸收作用的血管紧张素Ⅱ。ACE基因位于17q23,其中第16内含子存在一个插入/缺失(ID)型多态性,插入大小为287bp,并由Alu重复序列构成。本文探讨糖尿病视网膜病患者ACE基因多态性,并与无并发症的糖尿病患者组比较,旨在确定其基因与糖尿病视网膜病是否存在关联。
Late diabetic complications are mainly divided into small vessel disease (such as nephropathy, retinopathy) and macrovascular disease (such as cardiovascular disorders), is a major cause of disability and death in patients with diabetes. Research shows that the occurrence of these complications and genetic factors. The gene encoding the renin-angiotensin system protein product is a candidate gene associated with diabetic vascular disease complications. Angiotensin-converting enzyme (ACE) is an important component of the renin-angiotensin system that converts angiotensin I to vasoconstriction, promotes the proliferation of vascular and cardiac smooth muscle cells, and strengthens the renal sodium and sodium through the adrenal cortex aldosterone Absorption of angiotensin Ⅱ. The ACE gene is located at 17q23, in which there is an insertion / deletion (ID) polymorphism in the 16th intron. The insertion size is 287bp and consists of Alu repeats. This article explores ACE gene polymorphism in patients with diabetic retinopathy and compares it with diabetic patients without complications to determine if there is a link between their genes and diabetic retinopathy.