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E-Cadherin是跨膜糖蛋白家族中的一员,它系通过上皮细胞进行表达,并在组织细胞结构及向细胞内传递信息中起重要作用。E-Cadherin在肿瘤细胞上的表达缺失,被认为可导致肿瘤细胞分离并促进其浸润。 作者随机选用30例宫内膜癌患者的手术标本进行研究。研究采用E-cadherin单克隆抗体进行免疫组化检测E-cadherin在肿瘤细胞上的表达,并研究其与病理组织学改变的关系。判断检测结果,有以下三种类型:①阳性:与正常子宫内膜一样,为均匀的细颗粒染色;②不均匀型:指仅有部分肿瘤细胞染色阳性,或细胞边界有粗而不规则的染色颗粒;③阴
E-Cadherin is a member of the transmembrane glycoprotein family that is expressed by epithelial cells and plays an important role in the organization of cell structures and the transmission of information to cells. The loss of E-Cadherin expression on tumor cells is believed to result in tumor cell dissociation and promotion of infiltration. The authors randomly selected 30 cases of endometrial cancer patients with surgical specimens for study. E-cadherin monoclonal antibody was used to detect the expression of E-cadherin in tumor cells by immunohistochemistry, and to study its relationship with histopathological changes. Judgment test results, the following three types: ① positive: the same as the normal endometrium, uniform fine-grained; ② non-uniform type: only part of the tumor cells stained positive or rough and irregular cell boundaries Staining particles; ③ Yin