论文部分内容阅读
应用纯化的乙型肝炎病毒表面抗原（ＨＢｓＡｇ）免疫山羊，取其脾脏及淋巴结经匀浆透析法制备ＨＢｓＡｇ特异性转移因子（ＨＢｓＡｇ－ＳＴＦ）。在体外观察了其对外周血淋巴细胞增殖反应的影响。结果显示：慢性乙型肝炎患者外周血淋巴细胞增殖率明显低于正常人。ＨＢｓＡｇ－ＳＴＦ可明显促进患者外周血淋巴细胞的增殖反应，而正常转移因子（ＮＴＦ）对其作用则不明显。提示：慢性乙型肝炎患者的细胞免疫处于抑制状态。特异性转移因子可解除或缓解这种抑制状态。
HBsAg-specific transfer factor (HBsAg-STF) was prepared by immunizing goats with purified hepatitis B virus surface antigen (HBsAg) and collecting their spleens and lymph nodes by homogenization dialysis. Its effect on the proliferation of peripheral blood lymphocytes was observed in vitro. The results showed that: peripheral blood lymphocyte proliferation rate in patients with chronic hepatitis B was significantly lower than normal. HBsAg-STF can significantly promote the proliferation of patients with peripheral blood lymphocytes, while the role of normal transfer factor (NTF) was not obvious. Hint: Cellular immunity in patients with chronic hepatitis B is in an inhibitory state. Specific transfer factor can relieve or alleviate this state of inhibition.