用免疫组织化学ＰＡＰ法，对第１４～２１ｄ大鼠胚胎胰腺ＩＡＰＰ和Ｉｎｓ－ＩＲ细胞进行定位研究。结果显示，胚胎第１４ｄ胰腺内可见少数散在的Ｉｎｓ－ＩＲ细胞，未见ＩＡＰＰ－ＩＲ细胞；自胚胎第１６ｄ始，可见ＩＡＰＰ－ＩＲ细胞。经邻片比较证明，ＩＡＰＰ与Ｉｎｓ共存于胰岛Ｂ细胞内；随胎龄增长，ＩＡＰＰ和Ｉｎｓ－ＩＲ细胞相伴发育；同时在胰导管上皮细胞之间，出观察到共存的ＩＡＰＰ和Ｉｎｓ－ＩＲ细胞。本文还初步讨论了ＩＡＰＰ与Ｉｎｓ在大鼠胚胎胰腺内共存的生物学意义。 Immunohistochemical PAP method was used to locate the IAPP and Ins-IR cells in the fetal pancreas of the 14th to 21st day. The results showed that a small number of scattered Ins-IR cells were observed in the pancreas on the 14th day, and no IAPP-IR cells were observed. From the 16th day after embryo implantation, IAPP-IR cells were observed. IAPP and Ins coexist in pancreatic islet B cells by comparing adjacent cells. With the increase of gestational age, IAPP and Ins-IR cells coexist. In the meantime, IAPP and Ins-IR cells are observed between pancreatic ductal epithelial cells . This article also preliminary discussed the biological significance of the coexistence of IAPP and Ins in the rat embryonic pancreas.