“放心!你一定不会错过它,这就像是你走在路上,用余光瞥到了一只独角兽.鬼笔就是真菌里的非主流,一个个都穿着奇装异服,只需一眼,你就无法忽视它的存在.”这是江苏省中国科学院植物研究所的郑玉红老师带我在南京植物园里寻找鬼笔时说的话.rn鬼笔是大型真菌(子实体肉眼可见的真菌)中的一类,听名字就知道它们不是籍籍无名的角色.古人觉得它们的菌盖形似毛笔,其上往往还包裹着深色的黏液,如同蘸了墨汁一般,故以鬼笔命名.在我国最早关于鬼笔的记载出现于唐代,在中药学家陈藏器写的药物学名著《本草拾遗》中,就有对它的描述:“鬼笔生
Bile acids(BAs)are amphipathic molecules important for metabolism of cholesterol,absorp-tion of lipids and lipid soluble vitamins,bile flow,and regulation of gut microbiome.There are over 30 different BA species known to exist in humans and mice,which are
An essential step for cancer vaccination is to break the immunosuppression and elicit a tumor-specific immunity.A major hurdle against cancer therapeutic vaccination is the insufficient im-mune stimulation of the cancer vaccines and lack of a safe and eff
Drug transportation is impeded by various barriers in the hypoxic solid tumor,resulting in compromised anticancer efficacy.Herein,a solid lipid monostearin(MS)-coated CaO2/MnO2 nanocarrier was designed to optimize doxorubicin(DOX)transportation comprehens
Glioblastoma is carcinogenesis of glial cells in central nervous system and has the highest incidence among primary brain tumors.Brain metastasis,such as breast cancer and lung cancer,also leads to high mortality.The available medicines are limited due to
The bile acid-responsive G-protein-coupled receptor TGR5 is expressed in monocytes and macrophages,and plays a critical role in regulating inflammatory response.Our previous work has shown its role in promoting the progression of non-small cell lung cance
Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions.Cisplatin(CDDP)elicits nephrotoxicity due to exposure in proximal tubule cells during renal secretion.Alterations to renal drug transporter expressi
A chemical investigation on Sporormiella sp.led to the isolation and structural elucidation of tripodalsporormielones A-C(1-3),a new class of polyketide possessing unprecedented cage-like skel-etons with polyvdent bridged and fused ring systems.These poly
Pure drug-assembled nanomedicines(PDANs)are currently under intensive investigation as promising nanoplatforms for cancer therapy.However,poor colloidal stability and less tumor-homing ability remain critical unresolved problems that impede their clinical
中国是食用菌生产大国,在食用菌产量逐年增加的同时产生大量菌糠,需要对其进行“减量化、资源化、无害化”处理,但目前菌糠的利用率还很低.从菌糠再次用于栽培食用菌,及作为饲料、生态修复材料和化工材料等方面阐述食用菌菌糠的资源化利用现状,指出存在的问题,并提出加快利用建议.