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本文研究目的是评价格利克脲(Glidtazide)对非胰岛素依赖型糖尿病(NIDDM)血栓素 A_2(TXB_2)/前列环素(PGI_2)失衡及脂质/脂蛋白代谢的影响,认为该药对心血管疾病危险因素有防治作用。某些糖尿病人显示诸如血小板粘附,聚集增加,血小板寿命缩短出血异常以及纤溶改变造成一种促凝状态等血液学异常。高胰岛素血症被认为是心血管危险因子。X 综合征是与高胰岛素血症,胰岛素抵抗,糖耐量异常,极低密度脂蛋白(VLDL)
The aim of this study was to evaluate the effect of glidazole on the imbalance of TXB2 / PGI2 and lipid / lipoprotein metabolism in non-insulin dependent diabetes mellitus (NIDDM) Disease risk factors have preventive and therapeutic effects. Some people with diabetes show hematologic abnormalities such as platelet adhesion, increased aggregation, shortened platelet hemorrhage, and changes in fibrinolysis that cause a procoagulant state. Hyperinsulinemia is considered a cardiovascular risk factor. Syndrome X is associated with hyperinsulinemia, insulin resistance, impaired glucose tolerance, very low density lipoprotein (VLDL)