Ezrin蛋白是细胞膜-细胞微丝骨架连接蛋白ERM(Ezrin/Radixin/Moesin)蛋白家族的成员之一。作为酪氨酸激酶的底物,Ezrin蛋白能在细胞膜蛋白与肌动蛋白骨架之间发挥桥梁作用。近年,大量研究表明,Ezrin蛋白广泛参与食管癌细胞的增殖、凋亡、黏附以及侵袭转移等过程。上述过程不仅与Ezrin蛋白自身表达水平、亚细胞定位等改变密切相关,而且还受到原发食管癌细胞微环境改变的影响,同时也关联到CTGF或CYR61所参与的多条信号通路的交叉互动。明确Ezrin蛋白在食管癌发生发展中的作用及分子机制,可为食管癌的防治提供潜在的药物干预靶点,并为食管癌发生发展机制的阐明提供进一步的理论依据。 Ezrin is a member of the Ezrin / Radixin / Moesin (ERM) protein family. As a tyrosine kinase substrate, Ezrin protein can play a bridging role between cell membrane protein and actin skeleton. In recent years, a large number of studies have shown that Ezrin protein is widely involved in the proliferation, apoptosis, adhesion and invasion and metastasis of esophageal cancer cells. The above process is not only closely related to Ezrin protein expression, subcellular localization and other changes, but also to the primary esophageal cancer cell microenvironment changes, but also related to CTGF or CYR61 involved in the interaction of multiple signaling pathways. To clarify the role and molecular mechanism of Ezrin protein in the development and progression of esophageal cancer may provide a potential therapeutic target for the prevention and treatment of esophageal cancer and provide further theoretical evidence for the elucidation of the mechanism of esophageal cancer.