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125I是一种俄歇电子（Auger electron,AE）释放体,掺入细胞DNA后具有显著的细胞毒性。IUdR特异性掺入S期细胞DNA,是125I的良好转运载体。大量动物实验已证明:肿瘤局部直接持续和间隔反复注射125IUdR的抗肿瘤作用显著,疗效与肿瘤增殖动力学有关。由于神经组织的自身特点,125IUdR在脑胶质瘤治疗方面具有独特优势,能选择性杀伤肿瘤细胞,尤其对肿瘤残灶而言,故可作为外科手术的一项有益辅助治疗手段,提高胶质瘤患者的生存率。
125I is an Auger electron (AE) release body with significant cytotoxicity when incorporated into cellular DNA. IUdR specifically incorporates S-phase cellular DNA and is a good transporter of 125I. A large number of animal experiments have shown that: the local tumor directly and intermittently repeated injection of 125IUdR significant anti-tumor effect, efficacy and tumor proliferation kinetics. Because of its own characteristics of nerve tissue, 125IUdR has unique advantages in the treatment of glioma, can selectively kill tumor cells, especially for the residual tumor of the tumor, it can be used as a surgical adjuvant therapy to improve glial Tumor patient survival rate.