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为评价大扶康治疗急性白血病合并真菌感染的疗效及安全性，给３６ 例患者予大扶康治疗，３０ 例予酮康唑治疗，剂量分别为大扶康每次２００ ～４００ ｍ ｇ ，每日１ 次，酮康唑每次２００ ｍ ｇ ，每日２ 次。结果大扶康和酮康唑治疗深部真菌病的有效率分别为８４ ．６ ％ ，３３ ．３ ％ ，两组差异有高度显著性（ Ｐ ＜ ０ ．０１） ，而两组对浅部真菌病疗效差异无显著性（ Ｐ ＞ ０ ．０５） 。总有效率两组分别为９４ ．４ ％ ，７０ ％ ，两组差异有显著性（ Ｐ ＜ ０ ．０５） 。不良反应发生主要为胃肠道反应（１１ ．１ ％ ） ，提示大扶康治疗急性白血病并真菌感染安全有效。
To evaluate the efficacy and safety of DaFuKang in the treatment of acute leukemia complicated with fungal infections, 36 patients were treated with DaFuKang and 30 patients were treated with ketoconazole at doses of Diansang 200-400mg each time. Once a day, ketoconazole was administered 200 mg twice a day. Results The effective rates of Da Fu Kang and Ketoconazole in treating deep mycosis were 84. 6 %, 33. At 3%, the difference between the two groups was highly significant (P < .01). However, there was no significant difference between the two groups in the efficacy of superficial mycosis (P > 0.05). The total effective rate was 94 in the two groups. 40%, 70%, the difference between the two groups was significant (P < 0. 05). Adverse reactions occurred mainly in the gastrointestinal reaction (11.1%), suggesting that Dafukang is safe and effective in treating acute leukemia and fungal infections.