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目的 了解重症肝炎患者经Tα1免疫治疗前后外周血中 (TNF -α) ,sIL -2R ,IL -4 ,IL -6,内毒素及T细胞亚群 (CD+ 4,CD+ 8)的变化。方法 采用ELISA方法或合成基质偶氮显色法或链菌素亲生物素过氧化酶连接法检测上述指标。结果 治疗前各项指标较正常值均有明显改变 ,治疗后除sIL -2R和CD+ 4外 ,其他指标基本恢复到正常水平。结论 Tα1是强有力的免疫调节剂 ,能降低TNF -α ,sIL -2R ,IL -6,内毒素及CD+ 8含量 ,提高IL -4水平 ,从而减轻重症肝炎时免疫反应对肝细胞的损伤。
Objective To investigate the changes of TNF-α, sIL-2R, IL-4, IL-6, endotoxin and T cell subsets (CD 4, CD 8) in patients with severe hepatitis before and after Tα1 immunotherapy. Methods ELISA method or synthetic azo chromogenic method or streptavidin biotin peroxidase connection method to detect these indicators. Results Before treatment, all the indexes had significant changes compared with the normal values. After sIL-2R and CD + 4 treatment, other indexes returned to normal levels. Conclusion Tα1 is a potent immunomodulatory agent that can reduce the levels of TNF-α, sIL-2R, IL-6, endotoxin and CD + 8 and increase the level of IL-4, so as to reduce the damage of hepatocytes induced by immune response in severe hepatitis.