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本文研究了静滴Sulprostone(甲基磺酰胺前列腺素E_2的16-苯氧基衍化物)对子宫内死胎或水泡状胎块的堕胎和子宫排空效力及其副作用。自愿受试妇女中有7例为水泡状胎块(Ⅰ组),9例为妊娠小于24周的死胎(Ⅱ组)及12例为妊娠大于24周的死胎(Ⅲ组)。各组平均年龄相同,为29岁。用500ml等渗盐水将1,500μg的Sulprostone稀释后,以2～4μg/分钟静脉滴注6～8小时。在此以前受试者未接受其它药物治疗,堕胎过程中曾配合用度冷丁、镇痛新等镇痛药。受试者健康状况良好,无哮喘以及子宫切开或严重的肺、肝、肾等疾患。以堕胎得分来判断治疗效力。
This article investigates the efficacy and side effects of intravenous infusion of Sulprostone (16-phenoxyl derivate of methanesulfonamide prostaglandin E_2) on abortion and uterine bleeding in stillbirth or blister-shaped uterus. Seven of the volunteers were blisters (group I), nine were stillbirths less than 24 weeks of gestation (group II) and 12 were stillbirths of more than 24 weeks of gestation (group III). The average age of each group is the same, 29 years old. After diluting 1,500 μg of Sulprostone with 500 ml of isotonic saline, it is intravenously administered at 2 to 4 μg / min for 6 to 8 hours. Prior to this subject did not receive other drug treatment, abortion process with a cold cold, analgesic new analgesics. Subjects in good health, no asthma and uterine incision or severe lung, liver, kidney and other diseases. Abortion score to determine the efficacy of treatment.