摘要目的研究具有可待因咳嗽糖浆(CCS)依赖性男性青少年和年轻成年人大脑半球功能、解剖连接及其与冲动行为的关系。方法对33例依赖CCS的男性青少年、年轻成年人和38名健康对照组胼胝体(CC)体积和胼胝体5个亚区的体素镜像同伦功能连接(VMHC)进行比较,2组之间年龄、教育和吸烟情况相互配。Barratt冲动等级(BIS.11)用于评估参与者的冲动行为。组间比较后提取出显示异常CC亚区域和VMHC,并与冲动行为以及CCS服用时间进行相关性分析。 Abstract Objective To investigate the hemispheric function, anatomical connectivity and its relationship with impulsive behavior in the brain of codeine cough syrup (CCS) -dependent male and female adults. Methods 33 cases of CCS-dependent male adolescents, young adults and 38 healthy control group volume of the corpus callosum (CC) and corpus callosum five sub-regions of voxel homotypic functional connection (VMHC) were compared between the two groups of age, Education and smoking match each other. The Barratt Impulse Level (BIS.11) is used to assess participants’ impulsiveness. After the comparison between groups, the CC subregions and VMHC which showed abnormalities were extracted and correlated with impulsivity and CCS taking time.