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目的:用方差分析的方法评价肾气丸、右归丸和右归饮3首补肾阳类方的疗效,探究其中的核心药和边缘药以及核心药中的补阴药和补阳药之间的配伍规律。方法:把大鼠分为:正常组、肾阳虚模型组以及3首补肾阳类方各自的原方组、核心药组和边缘药组,共11组。分别检测其T、CORT、T4。利用方差分析的方法检验各个药方组药效的差别,结合9个药方组所含的药物及药量的不同分析不同药物配伍对药效的影响。结果:3首补肾阳类方的核心药组的药效均远高于边缘药组;核心药组中药效最好的是右归丸,而右归丸的核心药中补阳药与补阴药药味和药量都是3首补肾阳类方中最多的。结论:3首补肾阳类方的核心药均对提高药效起关键作用;补肾阳类方的配伍注重阴阳并补、阴阳互济,补阴药配伍补阳药构成该类方的基本组成。
OBJECTIVE: To evaluate the curative effect of “Shenqi Pill”, “Yougui Pill” and “Yougui Yin” on Kidney Yang Yang Prescription in three ways by means of analysis of variance (ANOVA), to explore the relationship between the core medicine and the peripheral medicine and the yin yin medicine and yang yang medicine Compatibility rules. Methods: The rats were divided into the normal group, the kidney yang deficiency model group and the three primary kidney yang side of the original group, the core group and the edge of the drug group, a total of 11 groups. They were detected T, CORT, T4. The variance analysis was used to test the difference of pharmacodynamics between different prescriptions. The effects of different pharmaceuticals on the pharmacodynamics were analyzed according to the different drugs and doses contained in the nine prescriptions. Results: The pharmacodynamics of the three main medicine groups were significantly higher than that of the marginal medicine group. The best medicine of the core medicine group was Yougui Wan, while the core medicine of You Gui Wan Yam drug flavor and dose are three kidney Yang side of the most. CONCLUSION: The three core drugs of Kidney-Yang Recipe have a key role in improving the efficacy. The compatibility of yang-invigorating and yang-invigorating prescriptions focuses on yin and yang, supplementation of yin and yang, yin-yang mutual-aid and yin yin compatibility.