含氟炔烃是一类亲双烯体和亲偶极体。当它发生 Diels-Alder 反应后,可生成单一的环加成产物;发生1,3-偶极环加成反应后,可生成各种含氟的杂环化合物。它可作为“结构单元”(building block)用于合成含氟有机化合物。近年来,随着含氟药物的发展,利用含氟炔烃可以制备具有生理活性的中间体,所以它的实际应用也更加令人感兴趣。这里从合成、反应和应用三个方面介绍近年来含氟炔烃的进展。 Fluorine-containing alkynes are a type of dienophile and dipolar dipole. When it occurs Diels-Alder reaction, can generate a single cycloaddition product; After 1,3-dipolar cycloaddition reaction, can generate a variety of fluorine-containing heterocyclic compounds. It can be used as a “building block” for the synthesis of fluorinated organic compounds. In recent years, with the development of fluorine-containing drugs, the use of fluorine-containing alkyne can be prepared with physiologically active intermediates, so its practical application is also more interesting. Here from the three aspects of synthesis, reaction and application of fluorine-containing alkyne progress in recent years.