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新黄皮酰胺系黄皮属植物(clausena lansium(Lour)skeels),所含新的具有降酶保肝活性的酰胺类化合物。它在植物中的含量低于0.01％。为了得到较多量的新黄皮酰胺供药理研究,我们按杨明河等报道的方法将含量较高的黄皮酰胺氧化、转化得到了新黄皮酰胺酮(Ⅰ)的外消旋体。然后再以硼氢化钠还原得到了新黄皮酰胺(Ⅱ_a)及其差向异构体——异新黄皮酰胺(Ⅱ_b)的混合物。
The new clavulanic acid type clam (Clausena lansium) (Lour) skeels), containing a new enzyme with liver enzyme activity of reducing amide. Its content in plants is less than 0.01%. In order to obtain a larger amount of neoacetamide for pharmacological studies, we reported the method of Yang Minghe higher content of the yellow amide, the conversion obtained neotame (1) racemate. And then sodium borohydride reduction to give a mixture of neotignin (II_a) and its epimerase-isoxanthone (II_b).