胰岛素样生长因子(IGF)是生长和生存必不可少的一类调控因子,可通过IGF受体介导作用,抑制细胞凋亡,促进细胞周期进程,血管生成和肿瘤的转移。近年来针对IGF系统进行癌症靶向治疗,已经取代了传统治疗手段,成为研究新热点。本文对IGF系统进行了概述,并综述了IGF与癌症发生的相关性以及IGF在肿瘤治疗领域中的应用前景。 Insulin-like growth factor (IGF) is an indispensable regulator of growth and survival, which can inhibit cell apoptosis, promote cell cycle progression, angiogenesis and tumor metastasis through IGF receptor mediation. In recent years, cancer targeting therapy targeting the IGF system has replaced the traditional treatment methods and has become a new hot spot for research. This article provides an overview of the IGF system and summarizes the relevance of IGF to cancer and the potential applications of IGF in the field of oncology.