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58％～90％接受血液透析的患者产生瘙痒,有人发现甲状旁腺切除术后患者顽固性的瘙痒消退,认为继发性的甲状旁腺功能亢进可能是致病原因。并非所有严重甲状旁腺功能亢进患者都有瘙痒,且术后患者以维生素D或钙剂补充治疗致高血钙时瘙痒可复发。P物质是一种能广泛分布于传入神经元的神经递质,它能将疼痛和瘙痒的感觉从外周传入中枢神经系统。辣椒素(capsaicin)能减少周围神经元中的P物质,阻断疼痛和病理性瘙痒的传输,作者过去的研究已证实外用辣椒素能明显减轻与血液
58% to 90% of patients receiving hemodialysis produce pruritus, it was found in patients with parathyroidectomy refractory itching subsided, that secondary hyperparathyroidism may be the cause of the disease. Not all patients with severe hyperparathyroidism have pruritus, and postoperative patients with vitamin D or calcium supplementation treatment induced hypercalcemia recurrence of itching. Substance P is a neurotransmitter that widely spreads to afferent neurons and transmits the sensation of pain and itch from the periphery into the central nervous system. Capsaicin reduces substance P in peripheral neurons and blocks the transmission of pain and pathological pruritus. Previous studies by the authors have shown that topical capsaicin can significantly reduce blood flow