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目的：评价顽固性青光眼滤过性手术中联合应用丝裂霉素Ｃ（ＭＭＣ）的近期眼压和视功能结果。方法：５１例６１眼顽固性青光眼，全部采用小梁切除术，术中联合应用ＭＭＣ，ＭＭＣ浓度为０．２ｍｇ／ｍｌ～０．４ｍｇ／ｍｌ，局部接触时间２～５分钟。结果：随访３～１８个月，５５眼（９０．１６％）眼压在不用药物情况下＜２１ｍｍＨｇ，视功能未恶化。并发症：白内障形成或加重１０眼，浅前房４２眼，脉络膜脱离６眼，低眼压性黄斑病变４眼。结论：小梁切除术联合术中应用ＭＭＣ在顽固性青光眼患者获得了满意的近期眼压控制效果。
Objective: To evaluate the recent intraocular pressure and visual function of mitomycin C (MMC) in refractory glaucoma filtration surgery. Methods: Totally 61 eyes (51 eyes) with refractory glaucoma were treated by trabeculectomy. The MMC and MMC concentrations were 0.2mg / ml ~ 0.4mg / ml and the local exposure time was 2-5 minutes. Results: During 3 to 18 months of follow-up, 55 eyes (90.16%) underwent intraocular pressure (IOP) <21 mmHg without medication, and their visual function did not deteriorate. Complications: cataract formation or aggravation of 10 eyes, 42 cases of shallow anterior chamber, choroidal detachment of 6 eyes, 4 eyes of low intraocular pressure macular degeneration. CONCLUSIONS: Trabeculectomy combined with intraoperative use of MMC has achieved satisfactory near-term IOP control in patients with refractory glaucoma.