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慢性肝病合并的胆汁淤积所致的皮肤搔痒比较顽固。我院自1990年2月～1997年7月应用纳络酮(Naloxone)治疗顽固性皮肤搔痒80例,这些病人曾用过异丙嗪、消胆胺(Cholestyramine可促进胆汁酸的排出)类树脂等治疗,但无明显效果。现报告如下:1 临床资料 80例病人,男58例,女22例,年龄39～68岁。慢性迁延性肝炎10例,慢性活动性肝炎55例,肝硬化15例。2 方法与结果 纳络酮系天桥(湖南)制药有限公司生产。用法:纳络酮2mg加5％GS500ml静脉滴注,1日1次,用至症状消失后停药,短者7天,长者30天。75例应用2天后开始减轻,
Chronic liver disease associated with cholestatic skin itching more stubborn. Our hospital from February 1990 to July 1997 application of naloxone (Naloxone) treatment of refractory pruritus 80 cases, these patients had used promethazine, cholestyramine (Cholestyramine can promote bile acid excretion) resin Other treatment, but no significant effect. Now report as follows: 1 Clinical data 80 patients, 58 males and 22 females, aged 39 to 68 years. 10 cases of chronic persistent hepatitis, 55 cases of chronic active hepatitis, liver cirrhosis in 15 cases. 2 Methods and Results Naloxone Department of bridge (Hunan) Pharmaceutical Co., Ltd. production. Usage: Naloxone 2mg plus 5% GS500ml intravenous infusion, 1, 1, until the symptoms disappear after discontinuation, a short period of 7 days, the elderly 30 days. 75 cases started to reduce after 2 days,