近年来的研究表明含非甲基化的ＣｐＧ双核甘酸结构域的ＤＮＡ可激发多种免疫反应 ,具有免疫激活功能 ,可用作诱导Ｔｈ1型特异性免疫反应的佐剂。本文就其发现、免疫刺激作用、免疫佐剂应用等作一综述。1　回顾90年代初 ,日本学者Ｙａｍａｍｏｔｏ等在进行抗肿瘤研究时发现 ,卡 Recent studies have shown that non-methylated CpG dinucleotide domain DNA can stimulate a variety of immune responses, with immune activation, can be used as an inducer of Th1-specific immune response. This article reviews the findings of immunostimulants, immune adjuvant applications and so on. 1 Recalling the early 90s, Japanese scholar Yamamoto et al found that anti-cancer study