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以硫氧化细菌使硫化矿物氧化是有效溶解金属硫化矿物产出强氧化性硫酸溶液的十分廉价的方法．智利、美国等国的大规模工厂用生物堆浸，每年可从低品位矿中生产１００万ｔ以上的铜。在搅拌槽中用生物浸出进行了钴黄铁矿浮选精矿的实验室及中间规模试验以分离难溶的有价金属，特别是镍、铜和钴．生物反应器的设计包括３个独立的试验阶段，最后阶段为６５ｍ３槽，现正运行，这是最后设计的工业生产槽。此外，回收钴的初始流程包括用沉淀法除铁和硫酸盐，接着用溶剂萃取铜来净化循环放出的浸出液。然后在第二溶剂萃取段进行钻液的净化和浓缩及反萃液电积提钴．
Oxidation of sulphide minerals with sulfur-oxidizing bacteria is a very inexpensive method of efficiently dissolving metal sulphide minerals to produce strongly oxidizing sulfuric acid solutions. Large-scale factories in Chile, the United States and other countries use bio-heap leachate to produce more than 1 million tonnes of copper per year from low-grade mines. Laboratory and intermediate scale tests of cobalt pyrite flotation concentrates were performed with bioleaching in a stirred tank to separate insoluble refractory metals, especially nickel, copper and cobalt. The bioreactor design consisted of three separate pilot stages, the final stage being a 65 m3 tank, which is now running, which is the final design of the industrial tank. In addition, the initial process for recovering cobalt includes removing iron and sulphate by precipitation followed by solvent extraction of copper to purify recycled leachate. Then in the second solvent extraction section of the drilling fluid purification and concentration and stripping liquid electrowinning cobalt.