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目的探讨冠状动脉粥样硬化性心脏病(CHD)患者血尿酸、胆红素水平及其影响因素。方法选取2014年1月至2015年1月沈阳市精神卫生中心收治的50例CHD患者作为研究对象,另选取同期健康体检者50例作为对照组。抽取CHD患者和健康体检者静脉血液测定血尿酸、胆红素水平。结果 CHD组患者的血尿酸明显高于对照组,总胆红素、直接胆红素、间接胆红素均明显低于对照组,差异均有统计学意义(均P<0.05);随冠状动脉狭窄程度加重,患者血尿酸水平呈递增趋势,总胆红素水平呈递减趋势,差异均有统计学意义(均P<0.05);抽烟患者的血尿酸水平明显高于非抽烟患者,总胆红素水平明显低于非抽烟组,差异均有统计学意义(均P<0.05);饮酒患者的血尿酸水平明显高于非饮酒患者,差异有统计学意义(P<0.05)。结论 CHD患者血尿酸、胆红素水平发生明显改变,与冠状动脉狭窄程度具有一定关系,且其受抽烟、饮酒影响。
Objective To investigate the levels of serum uric acid and bilirubin in patients with coronary atherosclerotic heart disease (CHD) and its influencing factors. Methods Fifty CHD patients admitted from January 2014 to January 2015 in Shenyang Mental Health Center were enrolled in this study. Another 50 healthy subjects were selected as the control group. Serum uric acid and bilirubin levels were measured in venous blood of CHD patients and healthy subjects. Results The serum uric acid in CHD group was significantly higher than that in control group. The levels of total bilirubin, direct bilirubin and indirect bilirubin in CHD group were significantly lower than those in control group (all P <0.05) The level of serum uric acid increased with the degree of stenosis increasing, while the level of total bilirubin decreased gradually (all P <0.05). The level of serum uric acid in smokers was significantly higher than that in non-smokers The level of serum uric acid was significantly higher in non-alcohol group than in non-smoking group (P <0.05). The difference was statistically significant (P <0.05). Conclusion Serum uric acid and bilirubin levels in patients with CHD significantly change, with a certain relationship with the degree of coronary artery stenosis, and its smoking, drinking influence.