论文部分内容阅读
目的探讨择性头部亚低温治疗新生儿缺氧缺血性脑病(HIE)患儿的临床效果。方法选取2014年5月至2015年5月河南省尉氏县妇幼保健院收治的110例HIE患儿作为研究对象,按随机数字表法将其分为对照组(48例)和研究组(62例)。对照组患儿给予常规治疗,研究组患儿在对照组基础上采用选择性头部亚低温进行治疗,比较两组患儿新生儿行为神经测定(NBNA)、智力发育指数(MDI)、运动发育指数(PDI)评分、血清细胞因子水平及不良事件发生情况。结果研究组患儿28 d的NBNA评分、12个月的MDI评分及PDI评分均明显高于对照组,差异均有统计学意义(均P<0.05);治疗72 h后,研究组患儿的血清浆内皮素-1(ET-1)、血清神经元特异性烯醇化酶(NSE)、白细胞介素-6(IL-6)水平均明显低于对照组,差异均有统计学意义(均P<0.05);研究组患儿不良事件总发生率明显低于对照组,差异有统计学意义(P<0.05)。结论选择性头部亚低温治疗HIE患儿不仅临床效果确切,可明显改善患儿神经及运动功能,而且安全系数较高。
Objective To investigate the clinical effect of selective head mild hypothermia on neonates with hypoxic-ischemic encephalopathy (HIE). Methods A total of 110 HIE children admitted to Weishi MCH from May 2014 to May 2015 were selected and divided into control group (48 cases) and study group (62 cases) according to random number table method example). Children in the control group were given routine treatment. The study group was treated with selective head mild hypothermia on the basis of the control group. The neonatal behavioral neurological assessment (NBNA), mental development index (MDI), motor development Index (PDI) score, serum cytokine levels and adverse events. Results The NBNA score, 12-month MDI score and PDI score of 28-day children in study group were significantly higher than those in control group (all P <0.05). After 72-hour treatment, the children in study group The levels of ET-1, NSE and IL-6 in serum were significantly lower than those in the control group P <0.05). The overall incidence of adverse events in the study group was significantly lower than that in the control group, the difference was statistically significant (P <0.05). Conclusion Selective head mild hypothermia in children with HIE is not only clinically effective, can significantly improve children with motor and nerve function, and higher safety factor.