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部分炎性肠道疾病,(Crohn简称CD,溃疡性结肠炎简称UC)病人可有胰腺、胆囊功能减退和十二指肠溃疡发生率增高,且可对食物发生异常的胃结肠反应,导致进食后腹泻,据认为上述表现均与肠肽有关。本研究调查了CD及UC病人在禁食及标准试餐后的血浆肠肽水平。方法:UC 24人、CD 14人,健康者14人作对照。禁食一夜,进食前3小时、餐后15、30、60、120及180分钟采血测血糖。用放射免疫法测定胃泌素、胰多肽(PP)、胰岛素、胃抑肽(GIP),血管活性肠肽(VIP),运动素(motilin),肠高血糖素及神经降压素(neurotensin)。为测定肠高血糖素,分别用羧基末端反应特异
Some patients with inflammatory bowel disease (Crohn referred to as CD, ulcerative colitis referred to as UC) may have pancreatic, gallbladder dysfunction and increased incidence of duodenal ulcer, and gastrointestinal reactions may occur abnormal food, leading to eating After diarrhea, it is believed that these findings are associated with intestinal peptide. This study investigated the plasma ghrelin levels of fasting and standard meals in CD and UC patients. Methods: 24 UC patients, 14 CD patients and 14 healthy controls were used as controls. Fasting overnight, 3 hours before eating, 15,30,60,120 and 180 minutes postprandial blood test blood glucose. Gastrin, pancreatic polypeptide (PP), insulin, GIP, VIP, motilin, glucagon and neurotensin were determined by radioimmunoassay. . For the determination of glucagon, the carboxy-terminal reaction is specific