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目的：研究氦氖激光血管内照射综合治疗对慢性肾小球疾病患者Ｔ细胞亚群的影响及疗效。方法：慢性肾小球疾病患者４９例与健康人相比，ＯＫＴ３、ＯＫＴ４降低，ＯＫＴ８增高，ＯＫＴ４／ＯＫＴ８比例降低（均Ｐ＜０．０１）。随机分为两组，激光综合治疗组２５例采用泼尼松、环磷酰胺联合氦氖激光血管内照射（ＩＬＩＢ）治疗，对照组２４例单用泼尼松和环磷酰胺治疗。结果：激光组ＯＫＴ８降低，ＯＫＴ４／ＯＫＴ８比例上升（Ｐ＜０．０１），疗效亦高于对照组，但差异无显著性（Ｐ＞０．０５）。结论：氦氖激光具有调整Ｔ淋巴细胞比例作用，从而提高疗效。
Objective: To study the effect of He-Ne laser intravascular irradiation on T cell subsets in patients with chronic glomerular disease. Methods: Compared with healthy controls, OKT3, OKT4 decreased, OKT8 increased and OKT4 / OKT8 decreased in 49 patients with chronic glomerular disease (all P <0.01). Randomly divided into two groups, laser treatment group 25 cases were treated with prednisone, cyclophosphamide combined with He-Ne laser intravascular irradiation (ILIB), control group, 24 cases were treated with prednisone and cyclophosphamide alone. Results: OKT8 decreased and OKT4 / OKT8 increased in laser group (P <0.01). The curative effect was also higher than that in control group, but the difference was not significant (P> 0.05). Conclusion: He-Ne laser has the effect of adjusting the proportion of T lymphocytes to improve the curative effect.