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[目的]观察恩替卡韦联合大黄蟅虫丸治疗慢性乙型肝炎早期肝硬化的临床疗效。[方法]将52例慢性乙型肝炎早期肝硬化患者随机分为对照组和观察组,每组26例。对照组予恩替卡韦分散片,0.5mg/次,1次/d,口服治疗,观察组在对照组治疗基础上加服大黄蟅虫丸,2丸/次,2次/d。2组均连续治疗24周,比较2组临床疗效、肝功能和肝纤维化指标变化。[结果]观察组临床疗效明显优于对照组,观察组肝功能和肝纤维化指标改善较对照组更明显(P<0.01)。[结论]恩替卡韦联合大黄蟅虫丸治疗慢性乙型肝炎早期肝硬化疗效显著。
[Objective] To observe the clinical efficacy of entecavir combined with rhubarb in the treatment of early liver cirrhosis of chronic hepatitis B. [Method] 52 cases of chronic hepatitis B patients with early liver cirrhosis were randomly divided into control group and observation group, with 26 cases in each group. The control group was given entecavir dispersible tablets, 0.5mg / time, 1 time / d, oral treatment, the observation group in the control group on the basis of treatment plus rhubarb Zhechong pill, 2 pills / time, 2 times / d. The two groups were treated for 24 weeks continuously, and the clinical curative effect, liver function and indexes of hepatic fibrosis were compared between the two groups. [Result] The clinical curative effect of the observation group was obviously better than that of the control group. The improvement of hepatic function and liver fibrosis in the observation group was more obvious than that in the control group (P <0.01). [Conclusion] The effect of entecavir combined with Rhubarb and Chronic Obsidian Pellet on the treatment of early liver cirrhosis in patients with chronic hepatitis B is significant.