1临床资料患者,女性,58岁,因反复四肢关节肿痛2年,双下肢浮肿1年入院。患者2007年6月无明显诱因下出现双手近端指间关节、掌指关节、双腕关节、双肩关节、双膝关节肿痛,晨僵1h,上述症状反复发作,1年前出现双下肢浮肿。无光敏、面部红斑、口腔溃疡,既往无肾病病史,曾间断服用中 1 Clinical data Patients, female, 58 years old, due to repeated limb pain, swelling and pain for 2 years, two-leg edema admitted to hospital for 1 year. Patients in June 2007 there was no obvious incentive to appear under the hands of the proximal interphalangeal joint, metacarpophalangeal joint, double wrist, double shoulder joint, double knee swelling and pain, morning stiffness 1h, the above symptoms recurrent, a year ago, lower extremity edema . No photosensitive, facial erythema, oral ulcers, no previous history of kidney disease, had taken intermittently