巨细胞病毒(CMV)是先天性病毒感染的主要病原,使相当一部分婴儿死亡或遗留神经系统精神运动性发育不全的后遗症,引起了人们的重视。然而,要继续更深入地研究CMV在母婴间的传播,却受到很大限制。人类CMV具有严格的种属特异性,无法在动物身上进行研究。因此人们致力于寻找合适的实验动物模型。小鼠CMV可侵犯胎盘,导致流产,但不发生宫内感染,不 Cytomegalovirus (CMV) is the main pathogen of congenital viral infection, causing a considerable number of infants to die or left nervous system sequelae of psychomotor hypoplasia has drawn people’s attention. However, continuing to study more deeply the spread of CMV between mother and child is very limited. Human CMV is strictly species-specific and can not be studied in animals. So people are committed to finding the right experimental animal model. Mouse CMV can invade the placenta, leading to abortion, but not intrauterine infection, no