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目的观察健康体检人群无症状脑梗死(silent cerebral infarction,SCI)的患病率、影像学特点,分析其相关危险因素。方法连续性收集第二军医大学长征医院贵宾诊疗科2006年5月至2010年3月行头颅磁共振(MRI)常规检查的1008例健康体检者,比较不同性别、年龄组间SCI患病率,概括其病灶特点,采用统计学方法分析各常见危险因素与SCI相关性。结果共发现328例SCI患者,患病率为32.5%,其中83.4%缺血灶为腔隙性脑梗死,好发于额叶、半卵圆中心、基底节区和侧脑室周围白质。单因素和多因素Logistic回归分析发现:年龄、高血压、糖尿病、低密度脂蛋白胆固醇、脂蛋白α、尿酸和颈动脉内中膜厚度在SCI和非SCI患者之间的差异有统计学意义,而且是SCI的独立危险因素。结论中国人群SCI发病率并不低,应引起重视并控制其危险因素。
Objective To observe the prevalence and imaging features of silent cerebral infarction (SCI) in health examination population and analyze the related risk factors. Methods The 1008 healthy subjects who underwent routine magnetic resonance (MRI) routine examination from May 2006 to March 2010 in VIP Clinic of Changzheng Hospital of Second Military Medical University were collected. The prevalences of SCI in different gender and age groups were compared. To summarize the characteristics of the lesions, statistical methods were used to analyze the correlation between the common risk factors and SCI. Results A total of 328 SCI patients were found, the prevalence was 32.5%. 83.4% of the ischemic lesions were lacunar infarcts, which occurred in the frontal lobe, the centrum, the basal ganglia and the periventricular white matter. Univariate and multivariate logistic regression analysis showed that the differences of age, hypertension, diabetes mellitus, low density lipoprotein cholesterol, lipoprotein α, uric acid and intima-media thickness of carotid arteries in SCI and non-SCI patients were statistically significant, But also an independent risk factor for SCI. Conclusions The incidence of SCI in Chinese population is not low, and should pay attention to and control its risk factors.