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为探讨慢性肾功能衰竭（ＣＲＦ）患者常伴有继发感染的原因，对急、慢性肾功能衰竭患者透析前后粒系、粒单系集落刺激因子（Ｇ－ＣＳＦ、ＧＭ－ＣＳＦ）水平进行了观察比较。结果表明，ＣＲＦ患者透析前后Ｇ－ＣＳＦ水平均较正常对照明显升高，透析后Ｇ－ＣＳＦ水平较透析前有升高，但无统计学差异，ＧＭ－ＣＳＦ水平透析前后与正常对照无统计学差异；急性肾功能衰竭（ＡＲＦ）患者透析前后Ｇ－ＣＳＦ、ＧＭ－ＣＳＦ水平比正常对照组明显升高，其中ＧＭ－ＣＳＦ水平ＡＲＦ患者透析前后均比ＡＲＦ患者明显为高。认为ＣＲＦ可影响血清集落刺激因子（ＣＳＦｓ）的产生，主要是ＧＭ－ＣＳＦ的产生，可能与慢性肾功能衰竭患者常伴有继发感染有关
To investigate the causes of secondary infection in patients with chronic renal failure (CRF), the levels of G-CSF and GM-CSF in patients with acute and chronic renal failure before and after dialysis Observe and compare. The results showed that the levels of G-CSF in CRF patients before and after dialysis were significantly higher than those in normal controls. The levels of G-CSF after dialysis were higher than those before dialysis, but there was no significant difference. The levels of GM-CSF before and after dialysis were not statistically different from the normal controls . The levels of G-CSF and GM-CSF in patients with acute renal failure (ARF) before and after dialysis were significantly higher than those in normal controls. The levels of GM-CSF in ARF patients before and after dialysis were significantly higher than those in ARF patients. CRF is thought to affect the production of serum CSFs, mainly GM-CSF, which may be associated with secondary infection in patients with chronic renal failure