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目的探讨淋巴细胞转化试验在肝炎后肝硬变患者的临床应用价值．方法以植物血凝素为有丝分裂原，应用３氚＿胸腺嘧啶核苷掺入技术，测定了肝炎后肝硬变患者４８例和健康对照者２２例外周血淋巴细胞转化能力．结果肝炎后肝硬变患者淋巴细胞转化能力较对照组明显下降（１８．０９±１３．０１比３４．８５±２１．７１，Ｐ＜００１）．根据Ｃｈｉｌｄ＿Ｐｕｇｈ分级、不同病程时的变化以及与凝血酶原活动度的相关性分析，可见肝脏损害越严重，淋巴细胞转化能力越低．结论肝炎后肝硬变患者存在细胞免疫功能的缺陷．其测定对了解肝脏的损害程度和储备能力有一定意义．
Objective To investigate the clinical value of lymphocyte transformation test in patients with posthepatitic cirrhosis. Methods Using phytohemagglutinin as mitogen, the ability of peripheral blood lymphocyte transformation in 48 patients with posthepatitic cirrhosis and 22 healthy controls was determined by using 3 tritiated thymidine incorporation technique. Results The ability of lymphocyte transformation in patients with posthepatitic cirrhosis was significantly lower than that of the control group (18.09 ± 13.01 vs. 34.85 ± 21.71, P <0.01). According to Child_Pugh classification, changes in different course of disease and correlation analysis with prothrombin activity, we can see the more serious liver damage, the lower the ability of lymphocyte transformation. Conclusion The patients with posthepatitic cirrhosis have the defects of cellular immune function. The determination of liver damage to understand the degree and reserve capacity of some significance.