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文献指出利福平可诱导环胞菌素的代谢,可使其谷浓度及全血AUC降低,但这一结论尚不肯定,其它药物如苯妥英、红霉素可影响环胞菌素的肝代谢,事实上也改变其吸收。本文研究了健康志愿者联用两药后环胞菌素(口服及静注)的药代动力学。方法6例(5男1女,24～46岁,57～100kg)体检正常,研究过程中禁用含咖啡因及醇的饮料。第一阶段,建立环胞菌素药代动力学,每日口服10mg·kg~(-1)及静滴3mgkg~(-1)(2h以上),两者相隔3d;第二阶段,联合用药
The literature points out that rifampin can induce the metabolism of cyclosporin, which can reduce its trough concentration and whole blood AUC, but this conclusion is not yet confirmed. Other drugs such as phenytoin and erythromycin can affect the hepatic metabolism of cyclosporine , In fact, change its absorption. This article studies the pharmacokinetics of cyclosporine (oral and intravenous) in healthy volunteers in combination with the two drugs. Methods Six patients (5 males and 1 females, 24 to 46 years old, 57 to 100 kg) had a normal physical examination. Caffeine and alcohol-containing beverages were banned during the study. The first phase, the establishment of cyclosporin pharmacokinetics, daily oral 10mg · kg ~ (1) and intravenous infusion of 3mgkg -1 (2h above), both separated by 3d; the second phase, combination therapy