骨髓间充质干细胞(BMSCs)在组织修复中具有重要的应用价值,它具有较低的免疫原性、自我更新能力和多向分化潜能,在一定的条件下体内外可以诱导分化为多种细胞类型。近年来研究表明力学因素通过多种信号途径可以影响BMSCs的多种生物学活性。综述了牵张应变、剪切应力、压应力和重力对BMSCs增殖、骨架和多向分化的影响。 Bone marrow mesenchymal stem cells (BMSCs) have an important application value in tissue repair. They have low immunogenicity, self-renewal ability and multidirectional differentiation potential. Under certain conditions, BMSCs can differentiate into many kinds of cells in vitro and in vivo Types of. In recent years, studies have shown that mechanical factors through a variety of signaling pathways can affect a variety of biological activity of BMSCs. The effects of tensile strain, shear stress, compressive stress and gravity on the proliferation, skeletal and multidirectional differentiation of BMSCs were reviewed.